HGNC ID: 6554
Target Abstract:
The leptin receptor (Leptin R), also known as OB-R or CD295, is encoded by the LEPR gene in humans. It functions as a receptor for the adipocyte-specific hormone leptin. Through hypothalamic actions on hunger and energy expenditure, leptin regulates adipose tissue mass upon binding to its receptor. Variants of the leptin receptor have been associated with diabetes mellitus and elevated susceptibility to histolytic amoebic infection.
LEPR Target Infomation Overview
- Target Symbol: LEPR, leptin receptor
- Gene Groups: CD molecules; Immunoglobulin like domain containing
- Alias: OBR; CD295
LEPR, leptin receptor Target Infomation by Species
- Human
- Mouse
- Rat
Human LEPR Target Information
- Target Symbol: LEPR, leptin receptor
- Alias:
- CD295
- DKFZp686B1731
- huB219
- LEP-R
- LEPRD
- OB receptor
- OB-R
- OBR
- NCBI_Gene: 3953
- UniProtKB: P48357
Human LEPR Predicted Functions
Enables identical protein binding activity and leptin receptor activity. Involved in several processes, including angiogenesis; leptin-mediated signaling pathway; and negative regulation of autophagy. Part of receptor complex. Implicated in several diseases, including artery disease (multiple); non-alcoholic fatty liver disease (multiple); obesity; obstructive sleep apnea; and type 2 diabetes mellitus. Biomarker of arteriosclerosis; chronic obstructive pulmonary disease; human immunodeficiency virus infectious disease; liver disease (multiple); and sleep apnea.
Mouse Lepr Target Information
- Target Symbol: Lepr, leptin receptor
- Alias:
- db
- diabetes
- Leprb
- LEPROT
- leptin receptor gene-related protein
- Modb1
- OB-RGRP
- obese-like
- obl
- Obr
- NCBI_Gene: 16847
Mouse Lepr Predicted Functions
Enables leptin receptor activity. Involved in several processes, including energy homeostasis; leptin-mediated signaling pathway; and positive regulation of cold-induced thermogenesis. Acts upstream of or within several processes, including glial cell proliferation; glycogen metabolic process; and negative regulation of gluconeogenesis. Predicted to be located in extracellular space and plasma membrane. Predicted to be part of receptor complex. Predicted to be active in external side of plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; limb segment; and skeleton. Used to study non-alcoholic fatty liver disease; obesity; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); non-alcoholic fatty liver disease (multiple); obesity; obstructive sleep apnea; and type 2 diabetes mellitus. Orthologous to human LEPR (leptin receptor).
Rat Lepr Target Information
- Target Symbol: Lepr, leptin receptor
- Alias:
- Fa
- LEP-R
- Leptin receptor (fatty)
- OB receptor
- OB-R
- NCBI_Gene: 24536
Rat Lepr Predicted Functions
Enables peptide hormone binding activity and protein-hormone receptor activity. Involved in several processes, including gonad development; negative regulation of locomotor rhythm; and positive regulation of cell communication. Located in extracellular space and plasma membrane. Used to study several diseases, including chronic kidney disease; glucose metabolism disease (multiple); obesity; pancreatitis; and renal fibrosis. Biomarker of pre-eclampsia and short bowel syndrome. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); non-alcoholic fatty liver disease (multiple); obesity; obstructive sleep apnea; and type 2 diabetes mellitus. Orthologous to human LEPR (leptin receptor).
