HGNC ID: 18363
Target Abstract:
Interleukin 29 (IL-29), also known as interferon λ1 (IFN-λ1), is a member of the helical cytokine family and is a type III interferon. Its amino acid sequence is highly similar to that of another type III interferon, IL-28.The IL-29 gene is found on human chromosome 19 but is absent from the mouse genome.IL-29 plays an important role in host defense against microorganisms, and its gene is highly up-regulated in virus-infected cells.IL-29 possesses significant antiviral activity and immunomodulatory properties, and can be activated by induction of IFN-α/β-like activation of cellular antiviral responses to inhibit viral replication. However, IL-29 is bound to a unique receptor, and thus this cytokine may act synergistically with IFN-α/β or IFN-γ to inhibit viral replication during natural infections, or in combination with other cytokines for the treatment of chronic viral infections such as hepatitis C (HCV).The antiviral activity of IL-29 includes up-regulation of class I MHC expression on cell surface and upregulation of PKR expression. The ligand/receptor complex appears to signal through the Jak-STAT pathway.
IFNL1 Target Infomation Overview
- Target Symbol: IFNL1, interferon lambda 1
- Gene Groups: Interferons
- Alias: IL-29
- Previous Names: IL29
- Alias Names: interleukin 29; interleukin 29 (interferon, lambda 1)
IFNL1, interferon lambda 1 Target Infomation by Species
Human
Mouse
Rat
Human IFNL1 Target Information
- Target Symbol: IFNL1, interferon lambda 1
- Alias:
- cytokine Zcyto21
- IFN-lambda-1
- IL-29
- IL29
- interferon lambda-1
- interferon-lambda-1
- interferon, lambda 1
- interleukin 29 (interferon, lambda 1)
- interleukin-29
- NCBI_Gene: 282618
- UniProtKB: Q8IU54
Human IFNL1 Predicted Functions
Enables interleukin-28 receptor binding activity. Involved in several processes, including negative regulation of immune response; positive regulation of macromolecule metabolic process; and regulation of gene expression. Located in extracellular region. Part of interleukin-28 receptor complex. Implicated in COVID-19; dengue hemorrhagic fever; hepatitis C; and hepatocellular carcinoma. Biomarker of asthma; dengue disease; subacute sclerosing panencephalitis; and tropical spastic paraparesis.
Mouse Ifnl2 Target Information
- Target Symbol: Ifnl2, interferon lambda 2
- Alias:
- EG330496
- Il28a
- interleukin 28A
- predicted gene, EG330496
- NCBI_Gene: 330496
Mouse Ifnl2 Predicted Functions
Predicted to enable interleukin-28 receptor binding activity. Involved in defense response to virus and mucosal immune response. Predicted to be located in extracellular region. Predicted to be part of interleukin-28 receptor complex. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in several diseases, including COVID-19; cryoglobulinemia; dengue hemorrhagic fever; hepatitis C; and liver disease (multiple). Orthologous to several human genes including IFNL2 (interferon lambda 2) and IFNL3 (interferon lambda 3).
Rat Ifnl1 Target Information
- Target Symbol: Ifnl1, interferon, lambda 1
- Alias:
- If1ia2
- interferon 1ia2
- interferon lambda-2-like
- interleukin-28A-like
- LOC100911249
- NCBI_Gene: 100911249
- UniProtKB: A0A0G2JWM7
Rat Ifnl1 Predicted Functions
Predicted to enable interleukin-28 receptor binding activity. Predicted to be involved in several processes, including defense response to other organism; negative regulation of immune response; and regulation of gene expression. Predicted to be located in extracellular region. Predicted to be part of interleukin-28 receptor complex. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in several diseases, including COVID-19; cryoglobulinemia; dengue hemorrhagic fever; hepatitis C; and liver disease (multiple). Orthologous to human IFNL1 (interferon lambda 1); IFNL2 (interferon lambda 2); and IFNL3 (interferon lambda 3).
