HGNC ID: 3763
Target Abstract:
Vascular endothelial growth factor receptor 1 (VEGF R1), also known as Flt-1, is a specific tyrosine kinase (RTK) receptor for angiogenic factors VEGF (VEGF-A), placental growth factor (PIGF), and VEGF-B. According to the shear form, there are two forms: membrane type (mbVEGFR) and soluble type (sVEGFR). Experimental and clinical injection of sVEGF R1 successfully prevented angiogenesis and tumor growth. The levels of sVEGF R1 in serum/plasma vary under different pathological conditions, which may have diagnostic value. Under experimental and pathological conditions, sVEGF R1 is correlated with VEGF levels. There are high levels of sVEGF R1 in the plasma of pregnant women and patients with primary hypertension. The levels of sVEGF R1 in the plasma of cardiovascular disease patients and smokers were significantly reduced.
FLT1 Target Infomation Overview
- Target Symbol: FLT1, fms related receptor tyrosine kinase 1
- Gene Groups: Receptor tyrosine kinases; I-set domain containing
- Alias: VEGFR1
- Previous Names: FLT
- Alias Names: vascular endothelial growth factor receptor 1; vascular permeability factor receptor; fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor); fms-related tyrosine kinase 1; fms related tyrosine kinase 1
FLT1, fms related receptor tyrosine kinase 1 Target Infomation by Species
- Human
- Mouse
- Rat
Human FLT1 Target Information
- Target Symbol: FLT1, fms related receptor tyrosine kinase 1
- Alias:
- FLT
- FLT-1
- fms related tyrosine kinase 1
- fms-like tyrosine kinase 1
- fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)
- tyrosine-protein kinase FRT
- tyrosine-protein kinase receptor FLT
- vascular endothelial growth factor receptor 1
- vascular permeability factor receptor
- VEGFR-1
- VEGFR1
- NCBI_Gene: 2321
- UniProtKB: P17948
Human FLT1 Predicted Functions
Enables growth factor binding activity; placental growth factor-activated receptor activity; and vascular endothelial growth factor-activated receptor activity. Involved in several processes, including monocyte chemotaxis; positive regulation of kinase activity; and protein phosphorylation. Located in actin cytoskeleton and plasma membrane. Is integral component of plasma membrane. Part of receptor complex. Implicated in Kuhnt-Junius degeneration; diabetic retinopathy; and pre-eclampsia. Biomarker of several diseases, including Kawasaki disease; Leydig cell tumor; cerebrovascular disease (multiple); kidney cancer (multiple); and retinal disease (multiple).
Mouse Flt1 Target Information
- Target Symbol: Flt1, FMS-like tyrosine kinase 1
- Alias:
- AI323757
- expressed sequence AI323757
- Flt-1
- sFlt1
- vascular endothelial growth factor receptor-1
- VEGFR-1
- VEGFR1
- NCBI_Gene: 14254
Mouse Flt1 Predicted Functions
Enables identical protein binding activity and vascular endothelial growth factor-activated receptor activity. Involved in several processes, including blood vessel morphogenesis; embryonic morphogenesis; and hyaloid vascular plexus regression. Acts upstream of or within several processes, including angiogenesis; positive regulation of hematopoietic progenitor cell differentiation; and post-embryonic camera-type eye morphogenesis. Located in extracellular space and nucleus. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; extraembryonic component; and genitourinary system. Human ortholog(s) of this gene implicated in Kuhnt-Junius degeneration; diabetic retinopathy; and pre-eclampsia. Orthologous to human FLT1 (fms related receptor tyrosine kinase 1).
Rat Flt1 Target Information
- Target Symbol: Flt1, Fms related receptor tyrosine kinase 1
- Alias:
- FLT-1
- FMS-like tyrosine kinase 1
- FMS-related tyrosine kinase 1
- Fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)
- LOC100911280
- tyrosine-protein kinase receptor FLT
- vascular endothelial growth factor receptor 1
- vascular endothelial growth factor receptor 1-like
- vascular endothelial growth factor/vascular permeability factor receptor
- VEGFR-1
- NCBI_Gene: 54251
Rat Flt1 Predicted Functions
Enables ATP binding activity; growth factor binding activity; and vascular endothelial growth factor-activated receptor activity. Involved in several processes, including liver regeneration; negative regulation of vascular endothelial growth factor production; and positive regulation of cell population proliferation. Located in extracellular space and plasma membrane. Used to study corneal neovascularization. Biomarker of breast cancer; diabetic retinopathy; liver cirrhosis; myocardial infarction; and vascular dementia. Human ortholog(s) of this gene implicated in Kuhnt-Junius degeneration; diabetic retinopathy; and pre-eclampsia. Orthologous to human FLT1 (fms related receptor tyrosine kinase 1).
