HGNC ID: 9666
Target Abstract:
CD45, also known as leukocyte common antigen (LCA), consists of a class of structurally similar transmembrane proteins with large molecular weights (180 kDa, 190 kDa, 205 kDa, and 200 kDa), which are widely present on the surface of all leukocytes (including lymphocytes, granulocytes, and monocytes), but are not expressed on CD45 cytoplasmic region has the role of protein tyrosine phosphatase, which can activate the tyrosine dephosphorylation on substrates P56lck and P59fyn, and plays an important role in cellular information transduction, CD45 is a key molecule of signaling on cell membrane, and has important significance in the development and maturation, functional regulation and signaling of lymphocytes. CD45 is a key signaling molecule in the cell membrane and is important in the development and maturation of lymphocytes, function regulation and signaling.The distribution of CD45 can be used as a classification marker for certain T cell subpopulations.
PTPRC Target Infomation Overview
- Target Symbol: PTPRC, protein tyrosine phosphatase receptor type C
- Gene Groups: CD molecules; Fibronectin type III domain containing; Protein tyrosine phosphatases receptor type
- Alias: LCA; T200; GP180
- Previous Names: CD45
PTPRC, protein tyrosine phosphatase receptor type C Target Infomation by Species
- Human
- Mouse
- Rat
Human PTPRC Target Information
- Target Symbol: PTPRC, protein tyrosine phosphatase receptor type C
- Alias:
- B220
- CD45
- CD45 antigen
- CD45R
- glycoprotein
- GP180
- L-CA
- LCA
- leukocyte common antigen
- leukocyte-common antigen
- LY5
- protein tyrosine phosphatase, receptor type, c polypeptide
- receptor-type tyrosine-protein phosphatase C
- T200
- T200 glycoprotein
- T200 leukocyte common antigen
- NCBI_Gene: 5788
- UniProtKB: P08575
Human PTPRC Predicted Functions
Enables cytoskeletal protein binding activity; protein kinase binding activity; and protein tyrosine phosphatase activity. Involved in several processes, including hematopoietic or lymphoid organ development; positive regulation of cell population proliferation; and regulation of protein kinase activity. Located in bleb and external side of plasma membrane. Implicated in hepatitis C; multiple sclerosis; severe combined immunodeficiency; and severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-positive, Nk cell-positive.
Mouse Ptprc Target Information
- Target Symbol: Ptprc, protein tyrosine phosphatase, receptor type, C
- Alias:
- B220
- CD45
- Cd45
- CD45 antigen
- Ly-5
- lymphocyte antigen 5
- Lyt-4
- T-lymphocyte antigen 4
- T200
- NCBI_Gene: 19264
Mouse Ptprc Predicted Functions
Enables several functions, including heparan sulfate proteoglycan binding activity; heparin binding activity; and protein tyrosine phosphatase activity. Involved in several processes, including lymphocyte differentiation; positive regulation of macromolecule metabolic process; and regulation of signal transduction. Acts upstream of or within several processes, including lymphocyte differentiation; positive regulation of lymphocyte activation; and regulation of protein phosphorylation. Located in external side of plasma membrane; focal adhesion; and membrane raft. Is expressed in several structures, including 3rd branchial arch; alimentary system; cardiovascular system; hemolymphoid system; and placenta. Used to study systemic lupus erythematosus. Human ortholog(s) of this gene implicated in hepatitis C; multiple sclerosis; severe combined immunodeficiency; and severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-positive, Nk cell-positive. Orthologous to human PTPRC (protein tyrosine phosphatase receptor type C).
Rat Ptprc Target Information
- Target Symbol: Ptprc, protein tyrosine phosphatase, receptor type, C
- Alias:
- CD45
- L-CA
- Lca
- leucocyte common antigen
- leukocyte common antigen
- leukocyte common antigen A
- leukocyte common antigen B
- Protein tyrosine phosphatase, receptor-type, c polypeptide
- receptor-type tyrosine-protein phosphatase C
- RT7
- T200
- T200 glycoprotein
- NCBI_Gene: 24699
- UniProtKB: P04157
Rat Ptprc Predicted Functions
Enables protein tyrosine phosphatase activity. Involved in T cell receptor signaling pathway; regulation of gene expression; and response to gamma radiation. Located in cell surface. Is integral component of plasma membrane. Human ortholog(s) of this gene implicated in hepatitis C; multiple sclerosis; severe combined immunodeficiency; and severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-positive, Nk cell-positive. Orthologous to human PTPRC (protein tyrosine phosphatase receptor type C).