HGNC ID: 2705
Target Abstract:
Decorin is a secreted proteoglycan rich in the leucine low molecular weight proteoglycan (SLRP) family. Decorin regulates the biological activity of extracellular collagen matrix and matrix related growth factors FGF, GDF-8/Myostatin, TGF-beta, and WISP-1. It also binds and activates EGF receptors, ErbB4, and IGF-1 receptors. Decorin promotes myoblast differentiation, supports angiogenesis, and inhibits tumor development. Research has shown that Decorin may have an inhibitory effect on the contraction of hypertrophic scars, indicating a certain role in preventing hypertrophic scar formation and promoting scar maturation.
DCN Target Infomation Overview
- Target Symbol: DCN, decorin
- Gene Groups: Small leucine rich repeat proteoglycans
- Alias: DSPG2; SLRR1B
- Alias Names: decorin proteoglycan
DCN, decorin Target Infomation by Species
- Human
- Mouse
- Rat
Human DCN Target Information
- Target Symbol: DCN, decorin
- Alias:
- bone proteoglycan II
- CSCD
- decorin proteoglycan
- dermatan sulphate proteoglycans II
- DSPG2
- PG-S2
- PG40
- PGII
- PGS2
- proteoglycan core protein
- SLRR1B
- small leucine-rich protein 1B
- NCBI_Gene: 1634
- UniProtKB: P07585
Human DCN Predicted Functions
Enables RNA binding activity. Involved in positive regulation of autophagy. Acts upstream of or within several processes, including positive regulation of mitochondrial depolarization; positive regulation of mitochondrial fission; and regulation of signal transduction. Located in extracellular space. Colocalizes with collagen-containing extracellular matrix. Implicated in breast carcinoma; congenital stromal corneal dystrophy; and high grade glioma. Biomarker of gestational diabetes and type 2 diabetes mellitus.
Mouse Dcn Target Information
- Target Symbol: Dcn, decorin
- Alias:
- DC
- SLRR1B
- NCBI_Gene: 13179
Mouse Dcn Predicted Functions
Enables extracellular matrix binding activity and glycosaminoglycan binding activity. Acts upstream of or within peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan. Located in collagen-containing extracellular matrix. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; genitourinary system; and sensory organ. Used to study Ehlers-Danlos syndrome and congenital stromal corneal dystrophy. Human ortholog(s) of this gene implicated in breast carcinoma; congenital stromal corneal dystrophy; and high grade glioma. Orthologous to human DCN (decorin).
Rat Dcn Target Information
- Target Symbol: Dcn, decorin
- Alias:
- bone proteoglycan II
- dermatan sulfate proteoglycan-II (decorin)
- DSPG
- MGC94682
- PG-S2
- PG40
- NCBI_Gene: 29139
- UniProtKB: Q01129
Rat Dcn Predicted Functions
Enables collagen binding activity and protein N-terminus binding activity. Involved in several processes, including animal organ development; response to lipopolysaccharide; and wound healing. Located in extracellular matrix. Part of collagen type VI trimer. Biomarker of asthma; myocardial infarction; and obesity. Human ortholog(s) of this gene implicated in breast carcinoma; congenital stromal corneal dystrophy; and high grade glioma. Orthologous to human DCN (decorin).
