HGNC ID: 11930
Target Abstract:
CD258, also known as LIGHT and tumor necrosis factor superfamily member 14 (TNFSF14), is a secreted protein belonging to the TNF superfamily. It is a type II transmembrane protein expressed on activated T cells and immature dendritic cells and recognized by the herpes virus invasion mediator (HVEM) and decoy receptor 3. The protein can be used as a co-stimulatory factor of lymphocyte activation and an inhibitor of herpes virus infection, which can stimulate the proliferation of T cells, cause apoptosis of various tumor cells and prevent virus invasion. It has also been reported to prevent TNF-α-mediated apoptosis in primary hepatocytes. In addition, CD258 is involved in T cell development and homeostasis, dendritic cell maturation, and atherosclerosis, and plays a significant role in diseases involving T cells such as graft-versus-host disease (GVHD) and autoimmune diseases.
TNFSF14 Target Infomation Overview
- Target Symbol: TNFSF14, TNF superfamily member 14
- Gene Groups: CD molecules; Tumor necrosis factor superfamily
- Alias: LIGHT; LTg; HVEM-L; CD258
- Alias Names: tumor necrosis factor (ligand) superfamily, member 14
TNFSF14, TNF superfamily member 14 Target Infomation by Species
- Human
- Mouse
- Rat
Human TNFSF14 Target Information
- Target Symbol: TNFSF14, TNF superfamily member 14
- Alias:
- CD258
- delta transmembrane LIGHT
- herpes virus entry mediator ligand
- herpesvirus entry mediator A
- herpesvirus entry mediator ligand
- herpesvirus entry mediator-ligand
- HVEML
- ligand for herpesvirus entry mediator
- LIGHT
- LTg
- TNLG1D
- TR2
- tumor necrosis factor (ligand) superfamily member 14
- tumor necrosis factor (ligand) superfamily, member 14
- tumor necrosis factor ligand 1D
- tumor necrosis factor ligand superfamily member 14
- tumor necrosis factor receptor-like 2
- tumor necrosis factor superfamily member 14
- tumor necrosis factor superfamily member LIGHT
- NCBI_Gene: 8740
- UniProtKB: O43557
Human TNFSF14 Predicted Functions
Enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process; identical protein binding activity; and signaling receptor binding activity. Involved in T cell costimulation; cellular response to mechanical stimulus; and positive regulation of NIK/NF-kappaB signaling. Predicted to be located in plasma membrane.
Mouse Tnfsf14 Target Information
- Target Symbol: Tnfsf14, tumor necrosis factor (ligand) superfamily, member 14
- Alias:
- HVEM-L
- LIGHT
- NCBI_Gene: 50930
Mouse Tnfsf14 Predicted Functions
Predicted to enable cysteine-type endopeptidase inhibitor activity involved in apoptotic process; identical protein binding activity; and signaling receptor binding activity. Acts upstream of or within several processes, including T cell costimulation; positive regulation of T cell chemotaxis; and positive regulation of myoblast fusion. Predicted to be located in plasma membrane. Used to study IgA glomerulonephritis. Orthologous to human TNFSF14 (TNF superfamily member 14).
Rat Tnfsf14 Target Information
- Target Symbol: Tnfsf14, TNF superfamily member 14
- Alias:
- LOC301133
- similar to Tumor necrosis factor ligand superfamily member 14 (CD258 antigen)
- Tnlg1d
- tumor necrosis factor (ligand) superfamily, member 14
- tumor necrosis factor ligand 1d
- tumor necrosis factor ligand superfamily member 14
- tumor necrosis factor superfamily member 14
- NCBI_Gene: 301133
- UniProtKB: M0RCN2
Rat Tnfsf14 Predicted Functions
Predicted to enable cysteine-type endopeptidase inhibitor activity involved in apoptotic process; identical protein binding activity; and signaling receptor binding activity. Predicted to be involved in cellular response to mechanical stimulus and positive regulation of NIK/NF-kappaB signaling. Predicted to act upstream of or within several processes, including T cell costimulation; positive regulation of T cell chemotaxis; and positive regulation of myoblast fusion. Predicted to be integral component of membrane. Orthologous to human TNFSF14 (TNF superfamily member 14).
