HGNC ID: 2432
Target Abstract:
Macrophage colony stimulating factor (M-CSF), also known as colony stimulating factor 1 (CSF1), is a cytokine secreted by osteoblasts. It is a hematopoietic growth factor that participates in the proliferation, differentiation, and survival of monocytes, macrophages, and bone marrow progenitor cells. M-CSF produced locally in the vascular wall will promote the process of atherosclerosis. M-CSF plays a role in kidney disease, including acute kidney injury (AKI) and chronic renal failure (CRF). Chronic activation of monocytes can lead to various metabolic, blood, and immune abnormalities in CRF patients. In AKI patients, M-CSF can promote repair, but it also has the opposite effect, promoting the proliferation of pro-inflammatory macrophages.
CSF1 Target Infomation Overview
- Target Symbol: CSF1, colony stimulating factor 1
- Alias: M-CSF; MCSF; MGC31930
- Alias Names: macrophage colony stimulating factor 1; colony stimulating factor 1 (macrophage)
CSF1, colony stimulating factor 1 Target Infomation by Species
- Human
- Mouse
- Rat
Human CSF1 Target Information
- Target Symbol: CSF1, colony stimulating factor 1
- Alias:
- colony stimulating factor 1 (macrophage)
- CSF-1
- lanimostim
- macrophage colony stimulating factor
- macrophage colony stimulating factor 1
- macrophage colony-stimulating factor 1
- MCSF
- MGC31930
- NCBI_Gene: 1435
- UniProtKB: P09603
Human CSF1 Predicted Functions
Enables cytokine activity; growth factor activity; and protein homodimerization activity. Involved in several processes, including positive regulation of cell differentiation; positive regulation of macromolecule metabolic process; and positive regulation of macrophage migration. Acts upstream of or within positive regulation of cell population proliferation. Located in several cellular components, including extracellular space; nuclear body; and perinuclear region of cytoplasm. Implicated in interstitial cystitis. Biomarker of several diseases, including COVID-19; atherosclerosis; end stage renal disease; glomerulonephritis (multiple); and vesicoureteral reflux.
Mouse Csf1 Target Information
- Target Symbol: Csf1, colony stimulating factor 1 (macrophage)
- Alias:
- C87615
- colony stimulating factor, macrophage
- colony-stimulating factor-1
- CSF-1
- Csfm
- expressed sequence C87615
- M-CSF
- op
- osteopetrosis
- NCBI_Gene: 12977
Mouse Csf1 Predicted Functions
Enables macrophage colony-stimulating factor receptor binding activity and protein homodimerization activity. Involved in several processes, including macrophage colony-stimulating factor signaling pathway; microglial cell proliferation; and positive regulation of gene expression. Acts upstream of or within several processes, including mammary gland development; osteoclast proliferation; and positive regulation of myeloid leukocyte differentiation. Located in extracellular space. Part of CSF1-CSF1R complex. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and hindlimb long bone. Used to study osteopetrosis. Human ortholog(s) of this gene implicated in interstitial cystitis. Orthologous to human CSF1 (colony stimulating factor 1).
Rat Csf1 Target Information
- Target Symbol: Csf1, colony stimulating factor 1
- Alias:
- colony stimulating factor 1 (macrophage)
- colony stimulating factor 1(macrophage)
- CSF-1
- macrophage colony-stimulating factor 1
- MCSF
- NCBI_Gene: 78965
Rat Csf1 Predicted Functions
Enables identical protein binding activity. Involved in several processes, including myeloid leukocyte differentiation; odontogenesis; and ossification. Located in extracellular space. Used to study anti-basement membrane glomerulonephritis; high grade glioma; and osteopetrosis. Biomarker of systemic scleroderma. Human ortholog(s) of this gene implicated in interstitial cystitis. Orthologous to human CSF1 (colony stimulating factor 1).
