HGNC ID: 10624
Target Abstract:
Chemokine C-C motif ligand 25 (CCL25), also known as thymus-expressed chemokine (TECK), is a chemokine produced by stromal cells of the thymus and by epithelial cells of the small intestine, particularly the jejunum and ileum.CCL25 induces the homing of several populations of lymphocytes to the small intestine, including the integrin a4b7 + & gamma;/δ T-cells, integrin aEb7 + CD8 + T cells, and IgA-producing plasma cells.CCL25 acts upon binding the chemokine receptor CCR9.CCL25 attracts CCR9 + monocytes and macrophages in rheumatoid arthritis and CCR9 + macrophages in atherosclerosis. In addition, CCL25 appears to be a new promising candidate for recruiting MSCs and therefore promoting in situ regeneration. In cancer, CCL25 promotes metastasis of melanoma cells to the small intestine, migration and invasion of certain breast cancers and attraction of MSC to multiple myeloma.
CCL25 Target Infomation Overview
- Target Symbol: CCL25, C-C motif chemokine ligand 25
- Gene Groups: Chemokine ligands
- Alias: TECK; Ckb15
- Previous Names: SCYA25
- Alias Names: Ck beta-15; thymus expressed chemokine; TECKvar; small inducible cytokine subfamily A (Cys-Cys), member 25; chemokine (C-C motif) ligand 25
CCL25, C-C motif chemokine ligand 25 Target Infomation by Species
- Human
- Mouse
- Rat
Human CCL25 Target Information
- Target Symbol: CCL25, C-C motif chemokine ligand 25
- Alias:
- C-C motif chemokine 25
- chemokine (C-C motif) ligand 25
- chemokine TECK
- Ck beta-15
- Ckb15
- MGC150327
- SCYA25
- small inducible cytokine subfamily A (Cys-Cys), member 25
- small-inducible cytokine A25
- TECK
- TECKvar
- thymus expressed chemokine
- thymus-expressed chemokine
- NCBI_Gene: 6370
- UniProtKB: O15444
Human CCL25 Predicted Functions
Enables CCR10 chemokine receptor binding activity and chemokine activity. Involved in several processes, including antimicrobial humoral immune response mediated by antimicrobial peptide; negative regulation of leukocyte tethering or rolling; and positive regulation of cell-matrix adhesion. Predicted to be located in extracellular region. Predicted to be active in extracellular space.
Mouse Ccl25 Target Information
- Target Symbol: Ccl25, chemokine (C-C motif) ligand 25
- Alias:
- AI852536
- CKb15
- expressed sequence AI852536
- Scya25
- small inducible cytokine A25
- TECK
- NCBI_Gene: 20300
Mouse Ccl25 Predicted Functions
Enables chemokine activity. Acts upstream of or within chemotaxis and leukocyte migration. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in 3rd branchial pouch; central nervous system; hemolymphoid system; retina; and thymus/parathyroid primordium. Orthologous to human CCL25 (C-C motif chemokine ligand 25).
Rat Ccl25 Target Information
- Target Symbol: Ccl25, C-C motif chemokine ligand 25
- Alias:
- C-C motif chemokine 25
- chemokine (C-C motif) ligand 25
- LOC360750
- MGC125074
- NCBI_Gene: 360750
- UniProtKB: Q32PX4
Rat Ccl25 Predicted Functions
Predicted to enable CCR10 chemokine receptor binding activity and chemokine activity. Predicted to be involved in several processes, including cellular response to cytokine stimulus; leukocyte chemotaxis; and negative regulation of leukocyte tethering or rolling. Predicted to act upstream of or within chemotaxis and leukocyte migration. Predicted to be active in extracellular space. Orthologous to human CCL25 (C-C motif chemokine ligand 25).
