HGNC ID: 1932
Target Abstract:
Chitinase-3-like protein 1 (CHI3L1) is secreted by various types of cells, including macrophages, chondrocytes, and certain tumor cells. The exact physiological function of CHI3L1 is still unknown, but it is involved in development and inflammatory diseases such as asthma and tumors. CHI3L1 is a cytokine that promotes Th2 response and is highly expressed in the tumor microenvironment and serum of cancer patients. Elevated expression of CHI3L1 is strongly associated with the stage and outcome of various types of tumors, suggesting that CHI3L1 can serve as a biomarker for disease severity. In animal models of glioblastoma multiforme, treatment with neutralizing antibodies against CHI3L1 has shown effectiveness. CHI3L1 can promote angiogenesis through both VEGF-dependent and VEGF-independent pathways. Additionally, CHI3L1 has been shown to enhance tumor cell survival under gamma radiation.
CHI3L1 Target Infomation Overview
- Target Symbol: CHI3L1, chitinase 3 like 1
- Gene Groups: Chitinases
- Alias: GP39; YKL40; YK-40
- Alias Names: cartilage glycoprotein-39; chitinase 3-like 1 (cartilage glycoprotein-39)
CHI3L1, chitinase 3 like 1 Target Infomation by Species
- Human
- Mouse
- Rat
Human CHI3L1 Target Information
- Target Symbol: CHI3L1, chitinase 3 like 1
- Alias:
- 39 kDa synovial protein
- ASRT7
- cartilage glycoprotein 39
- CGP-39
- chitinase 3-like 1 (cartilage glycoprotein-39)
- chitinase-3-like protein 1
- DKFZp686N19119
- FLJ38139
- GP-39
- GP39
- HC-gp39
- hCGP-39
- HCGP-3P
- YK-40
- YKL-40
- YKL40
- YYL-40
- NCBI_Gene: 1116
- UniProtKB: P36222
Human CHI3L1 Predicted Functions
Enables chitin binding activity. Involved in several processes, including positive regulation of intracellular signal transduction; response to interleukin-1; and response to interleukin-6. Located in extracellular space. Implicated in asthma and schizophrenia. Biomarker of several diseases, including artery disease (multiple); autoimmune disease (multiple); bone cancer (multiple); lung disease (multiple); and reproductive organ cancer (multiple).
Mouse Chil1 Target Information
- Target Symbol: Chil1, chitinase-like 1
- Alias:
- AW208766
- Brp39
- Chi3l1
- chitinase 3-like 1
- expressed sequence AW208766
- glycoprotein 39
- Gp39
- NCBI_Gene: 12654
Mouse Chil1 Predicted Functions
Predicted to enable chitin binding activity. Involved in positive regulation of interleukin-8 production; positive regulation of protein kinase B signaling; and positive regulation of protein phosphorylation. Located in endoplasmic reticulum. Is expressed in alimentary system; limb; and skeleton. Human ortholog(s) of this gene implicated in asthma and schizophrenia. Orthologous to human CHI3L1 (chitinase 3 like 1).
Rat Chi3l1 Target Information
- Target Symbol: Chi3l1, chitinase 3 like 1
- Alias:
- cartilage glycoprotein 39
- CGP-39
- Chil1
- chitinase 3-like 1
- chitinase 3-like 1 (cartilage glycoprotein-39)
- chitinase-3-like protein 1
- GP-39
- MGC109420
- NCBI_Gene: 89824
Rat Chi3l1 Predicted Functions
Predicted to enable chitin binding activity. Involved in cellular response to interleukin-1; cellular response to tumor necrosis factor; and inflammatory response. Located in extracellular space. Biomarker of hypertension. Human ortholog(s) of this gene implicated in asthma and schizophrenia. Orthologous to human CHI3L1 (chitinase 3 like 1).
