HGNC ID: 603
Target Abstract:
Apolipoprotein B (Apo B) is the major apolipoprotein found in chylomicrons, very low-density lipoproteins (VLDL), intermediate-density lipoproteins (IDL), and low-density lipoproteins (LDL). It is responsible for transporting lipid molecules (lipids). Due to differences in amino acid composition, Apo B can be divided into two subtypes: Apo B48 and Apo B100. Elevated levels of Apo B, particularly when combined with high levels of LDL, are a major driving force behind vascular diseases such as atherosclerosis. Excess Apo B in the liver leads to lipid-induced endoplasmic reticulum stress and insulin resistance. Studies have shown that the Apo B100/Apo A1 ratio is more effective in predicting the risk of cardiac events in patients with acute myocardial infarction compared to measuring Apo B-100 or Apo A1 alone.
APOB Target Infomation Overview
- Target Symbol: APOB, apolipoprotein B
- Gene Groups: Apolipoproteins
- Alias Names: apolipoprotein B (including Ag(x) antigen)
APOB, apolipoprotein B Target Infomation by Species
- Human
- Mouse
- Rat
Human APOB Target Information
- Target Symbol: APOB, apolipoprotein B
- Alias:
- apo B-100
- apoB-100
- apoB-48
- apolipoprotein B (including Ag(x) antigen)
- apolipoprotein B-100
- apolipoprotein B48
- FCHL2
- FLDB
- LDLCQ4
- mutant Apo B 100
- NCBI_Gene: 338
- UniProtKB: P04114
Human APOB Predicted Functions
Enables several functions, including cholesterol transfer activity; heparin binding activity; and lipase binding activity. Involved in several processes, including cholesterol homeostasis; low-density lipoprotein particle clearance; and low-density lipoprotein particle remodeling. Located in cytosol; endoplasmic reticulum exit site; and neuronal cell body. Part of low-density lipoprotein particle; mature chylomicron; and triglyceride-rich plasma lipoprotein particle. Implicated in several diseases, including artery disease (multiple); biliary tract cancer (multiple); familial hyperlipidemia (multiple); hypobetalipoproteinemia (multiple); and sickle cell anemia. Biomarker of several diseases, including common bile duct neoplasm; diabetes mellitus (multiple); familial combined hyperlipidemia; hypobetalipoproteinemia; and obesity.
Mouse Apob Target Information
- Target Symbol: Apob, apolipoprotein B
- Alias:
- AI315052
- apob-100
- apob-48
- expressed sequence AI315052
- NCBI_Gene: 238055
Mouse Apob Predicted Functions
Predicted to enable several functions, including cholesterol transfer activity; heparin binding activity; and lipase binding activity. Acts upstream of or within several processes, including cholesterol efflux; lipoprotein metabolic process; and triglyceride metabolic process. Located in endoplasmic reticulum. Is expressed in several structures, including adrenal gland; brain; extraembryonic component; genitourinary system; and gut. Used to study familial hypobetalipoproteinemia 2. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); biliary tract cancer (multiple); familial hyperlipidemia (multiple); hypobetalipoproteinemia (multiple); and sickle cell anemia. Orthologous to human APOB (apolipoprotein B).
Rat Apob Target Information
- Target Symbol: Apob, apolipoprotein B
- Alias:
- Aa1064
- Ac1-060
- Apo B-100
- ApoB-100
- ApoB-48
- apolipoprotein B (including Ag(x) antigen)
- apolipoprotein B PI
- apolipoprotein B-100
- apolipoprotein B-48
- NCBI_Gene: 54225
Rat Apob Predicted Functions
Predicted to enable several functions, including cholesterol transfer activity; heparin binding activity; and lipase binding activity. Involved in several processes, including cellular response to tumor necrosis factor; response to estradiol; and triglyceride catabolic process. Located in several cellular components, including extracellular space; vesicle lumen; and vesicle membrane. Part of high-density lipoprotein particle; low-density lipoprotein particle; and very-low-density lipoprotein particle. Biomarker of fatty liver disease and nephrotic syndrome. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); biliary tract cancer (multiple); familial hyperlipidemia (multiple); hypobetalipoproteinemia (multiple); and sickle cell anemia. Orthologous to human APOB (apolipoprotein B).
