HGNC ID: 7380
Target Abstract:
Macrophage stimulating proteins (MSP), also known as hepatocyte growth factor-like proteins (HGFL) and MST1, are members of the HGF family of growth factors. MSP is secreted in the form of inactive single-stranded precursors (pro-MSP) that are ligands of the transmembrane receptor tyrosine kinase receptor (RON) (RON; Also known as MST1R). Since its discovery, MSP has been shown to play a key role in regulating inflammation in peripheral tissues in a variety of disease models. Recent evidence also suggests that MSP has a beneficial role in regulating lipid and glucose metabolism in the liver, thereby hinting at MSP as a key regulator in maintaining metabolic homeostasis while inhibiting inflammatory processes. MSP induces proliferation of macrophages and keratinocytes and activation of osteoclasts. It also inhibits LPS or IFN-induced iNOS and IL-12 expression by macrophages and prevents apoptosis of epithelial cells isolated from extracellular matrix.
MST1 Target Infomation Overview
- Target Symbol: MST1, macrophage stimulating 1
- Alias: MSP; NF15S2
- Previous Names: D3F15S2; HGFL; DNF15S2
- Alias Names: hepatocyte growth factor-like
MST1, macrophage stimulating 1 Target Infomation by Species
- Human
- Mouse
- Rat
Human MST1 Target Information
- Target Symbol: MST1, macrophage stimulating 1
- Alias:
- D3F15S2
- DNF15S2
- hepatocyte growth factor-like protein
- hepatocyte growth factor-like protein homolog
- HGFL
- macrophage stimulating 1 (hepatocyte growth factor-like)
- macrophage stimulatory protein
- macrophage-stimulating protein
- MSP
- NF15S2
- NCBI_Gene: 4485
- UniProtKB: P26927
Human MST1 Predicted Functions
Enables receptor tyrosine kinase binding activity. Involved in histone H2A-S139 phosphorylation; negative regulation of gluconeogenesis; and regulation of cAMP-dependent protein kinase activity. Located in extracellular space. Part of collagen-containing extracellular matrix.
Mouse Mst1 Target Information
- Target Symbol: Mst1, macrophage stimulating 1 (hepatocyte growth factor-like)
- Alias:
- D3F15S2h
- D9H3F15S2
- DNA segment, Chr 9, human D3F15S2
- DNF15S2h
- hepatocyte growth factor-like
- Hgfl
- NCBI_Gene: 15235
Mouse Mst1 Predicted Functions
Predicted to enable receptor tyrosine kinase binding activity. Acts upstream of or within several processes, including embryo implantation; mammary duct terminal end bud growth; and positive regulation of mammary gland epithelial cell proliferation. Located in vacuole. Is expressed in esophagus epithelium; liver; liver parenchyma; pharynx epithelium; and stomach proventricular region epithelium. Orthologous to several human genes including MST1 (macrophage stimulating 1).
Rat Mst1 Target Information
- Target Symbol: Mst1, macrophage stimulating 1
- Alias:
- D8h3f15s2
- E2F transcription factor 2
- E2F2
- hepatocyte growth factor-like protein
- Macrophage stimulating 1 (hepatocyte growth factor-like)
- NCBI_Gene: 24566
Rat Mst1 Predicted Functions
Enables enzyme binding activity. Involved in cellular response to hypoxia; flagellated sperm motility; and spermatogenesis. Located in cytoplasm. Orthologous to several human genes including MST1 (macrophage stimulating 1).
