HGNC ID: 11929
Target Abstract:
B cell activating factor (BAFF), also known as B lymphocyte stimulating factor (BLys) or tumor necrosis factor ligand superfamily member 13B(TNFSF13B), is expressed in B cell line cells and plays an important role in the proliferation and differentiation of B cells as a potent B cell activator. BAFF acts as an immune stimulant and is necessary to maintain normal immunity. Underexpression of BAFF will not activate B cells to produce sufficient immunoglobulins and lead to immune deficiency. Overexpression of BAFF can lead to oversecretion of antibodies, leading to systemic lupus erythematosus, rheumatoid arthritis and other autoimmune diseases.
TNFSF13B Target Infomation Overview
- Target Symbol: TNFSF13B, TNF superfamily member 13b
- Gene Groups: CD molecules; Tumor necrosis factor superfamily
- Alias: BAFF; THANK; BLYS; TALL-1; TALL1; CD257
- Previous Names: TNFSF20
- Alias Names: B-cell-activating factor; TNF and ApoL-related leukocyte expressed ligand 1; TNF homolog that activates apoptosis; B-lymphocyte stimulator; tumor necrosis factor (ligand) superfamily, member 13b
TNFSF13B, TNF superfamily member 13b Target Infomation by Species
- Human
- Mouse
- Rat
Human TNFSF13B Target Information
- Target Symbol: TNFSF13B, TNF superfamily member 13b
- Alias:
- ApoL related ligand TALL-1
- b lymphocyte stimulator
- B-cell activating factor
- B-cell-activating factor
- B-lymphocyte stimulator
- BAFF
- BLYS
- CD257
- delta BAFF
- Delta4 BAFF
- dendritic cell-derived TNF-like molecule
- DTL
- TALL-1
- TALL1
- THANK
- TNF and ApoL-related leukocyte expressed ligand 1
- TNF homolog that activates apoptosis
- TNF- and APOL-related leukocyte expressed ligand 1
- TNFSF20
- TNLG7A
- tumor necrosis factor (ligand) superfamily member 13b
- tumor necrosis factor (ligand) superfamily, member 13b
- tumor necrosis factor (ligand) superfamily, member 20
- tumor necrosis factor ligand 7A
- tumor necrosis factor ligand superfamily member 13B
- tumor necrosis factor superfamily member 13b
- tumor necrosis factor superfamily, member 13b
- tumor necrosis factor-like protein ZTNF4
- ZTNF4
- NCBI_Gene: 10673
- UniProtKB: Q9Y275
Human TNFSF13B Predicted Functions
Predicted to enable receptor ligand activity. Involved in positive regulation of B cell proliferation. Located in several cellular components, including focal adhesion; perinuclear region of cytoplasm; and plasma membrane.
Mouse Tnfsf13b Target Information
- Target Symbol: Tnfsf13b, tumor necrosis factor (ligand) superfamily, member 13b
- Alias:
- BAFF
- BLyS
- D8Ertd387e
- DNA segment, Chr 8, ERATO Doi 387, expressed
- TALL-1
- zTNF4
- NCBI_Gene: 24099
Mouse Tnfsf13b Predicted Functions
Predicted to enable receptor ligand activity. Involved in B cell differentiation and tumor necrosis factor-mediated signaling pathway. Acts upstream of or within B cell homeostasis; positive regulation of germinal center formation; and positive regulation of lymphocyte activation. Predicted to be located in several cellular components, including focal adhesion; perinuclear region of cytoplasm; and plasma membrane. Predicted to be active in extracellular space. Is expressed in genitourinary system. Used to study IgA glomerulonephritis and Sjogren’s syndrome. Orthologous to human TNFSF13B (TNF superfamily member 13b).
Rat Tnfsf13b Target Information
- Target Symbol: Tnfsf13b, TNF superfamily member 13b
- Alias:
- B-cell-activating factor
- BAFF
- LOC498666
- RGD1561519
- similar to NZB B-cell activating factor
- Tnlg7a
- tumor necrosis factor (ligand) superfamily, member 13b
- tumor necrosis factor ligand 7a
- tumor necrosis factor ligand superfamily member 13B
- tumor necrosis factor superfamily member 13b
- NCBI_Gene: 498666
Rat Tnfsf13b Predicted Functions
Predicted to enable receptor ligand activity. Predicted to be involved in B cell differentiation; positive regulation of B cell proliferation; and tumor necrosis factor-mediated signaling pathway. Predicted to act upstream of or within B cell homeostasis; positive regulation of germinal center formation; and positive regulation of lymphocyte activation. Predicted to be located in several cellular components, including focal adhesion; perinuclear region of cytoplasm; and plasma membrane. Predicted to be active in extracellular space. Orthologous to human TNFSF13B (TNF superfamily member 13b).
