HGNC ID: 1073
Target Abstract:
Bone Morphogenetic Protein 6 (BMP-6) is a member of the TGF-β superfamily encoded by the BMP6 gene. Bone morphogenetic proteins are known to induce the growth of bone and cartilage. BMP-6 has been shown to induce the expression of markers for osteoblasts, which are cells responsible for bone formation, in mesenchymal stem cells. In addition, a study published in the journal “Nature Genetics" in 2009 described another function of BMP-6. It was identified as a key regulator of hepcidin, a small peptide secreted by the liver and the major regulator of mammalian iron metabolism.
BMP6 Target Infomation Overview
- Target Symbol: BMP6, bone morphogenetic protein 6
- Gene Groups: Bone morphogenetic proteins
- Alias: VGR1
- Previous Names: VGR
- Alias Names: vegetal related growth factor (TGFB-related)
BMP6, bone morphogenetic protein 6 Target Infomation by Species
- Human
- Mouse
- Rat
Human BMP6 Target Information
- Target Symbol: BMP6, bone morphogenetic protein 6
- Alias:
- BMP-6
- vegetal related growth factor (TGFB-related)
- vegetal-related (TGFB related) cytokine
- VG-1-R
- VG-1-related protein
- Vg1-related sequence
- VGR
- VGR-1
- VGR1
- NCBI_Gene: 654
- UniProtKB: P22004
Human BMP6 Predicted Functions
Enables BMP receptor binding activity and protein heterodimerization activity. Involved in several processes, including negative regulation of adherens junction organization; positive regulation of macromolecule metabolic process; and transmembrane receptor protein serine/threonine kinase signaling pathway. Predicted to be located in cytoplasm and vesicle. Predicted to be active in extracellular space. Biomarker of breast cancer; esophagus squamous cell carcinoma; prostate cancer; and renal cell carcinoma.
Mouse Bmp6 Target Information
- Target Symbol: Bmp6, bone morphogenetic protein 6
- Alias:
- D13Wsu115e
- DNA segment, Chr 13, Wayne State University 115, expressed
- Vg-1 related protein 1
- Vgr1
- NCBI_Gene: 12161
Mouse Bmp6 Predicted Functions
Predicted to enable BMP receptor binding activity; protein heterodimerization activity; and receptor ligand activity. Involved in several processes, including iron ion homeostasis; positive regulation of signal transduction; and regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including endochondral ossification; male genitalia development; and osteoblast differentiation. Located in extracellular space. Is expressed in several structures, including alimentary system; central nervous system; female reproductive system; sensory organ; and skeleton. Orthologous to human BMP6 (bone morphogenetic protein 6).
Rat Bmp6 Target Information
- Target Symbol: Bmp6, bone morphogenetic protein 6
- Alias:
- BMP-6
- VG-1-related protein
- VGR
- VGR-1
- NCBI_Gene: 25644
- UniProtKB: Q04906
Rat Bmp6 Predicted Functions
Enables growth factor activity. Involved in several processes, including cellular response to mechanical stimulus; positive regulation of aldosterone secretion; and positive regulation of cell differentiation. Located in cytoplasm; extracellular space; and vesicle. Biomarker of anemia; brain ischemia; and colitis. Orthologous to human BMP6 (bone morphogenetic protein 6).
