HGNC ID: 484
Target Abstract:
Angiopoietins are part of the vascular endothelial growth factor (VEGF) family and play a role in embryonic and neo-vascularization. Angiopoietin cytokines regulate microvascular permeability, vasodilation, and vasoconstriction by signaling to the surrounding smooth muscle cells. Angiopoietin-1 (ANG-1) is encoded by a gene that produces a 498 amino acid peptide with a molecular weight of 57 kDa. It can form dimers, trimers, and tetramers. ANG-1 plays an important role in vascular maturation, adhesion, migration, and survival. Studies have shown an increased ratio of ANG-2 to ANG-1 in the serum, indicating dysregulation of the angiopoietin and tyrosine kinase pathway, which is common in blood-related diseases such as diabetes, malaria, sepsis, and pulmonary arterial hypertension.
ANGPT1 Target Infomation Overview
- Target Symbol: ANGPT1, angiopoietin 1
- Gene Groups: Receptor ligands; Fibrinogen C domain containing
- Alias: KIAA0003; Ang1
ANGPT1, angiopoietin 1 Target Infomation by Species
- Human
- Mouse
- Rat
Human ANGPT1 Target Information
- Target Symbol: ANGPT1, angiopoietin 1
- Alias:
- AGP1
- AGPT
- ANG-1
- ANG1
- angiopoietin-1
- HAE5
- NCBI_Gene: 284
- UniProtKB: Q15389
Human ANGPT1 Predicted Functions
Enables receptor tyrosine kinase binding activity. Involved in several processes, including positive regulation of intracellular signal transduction; positive regulation of macromolecule metabolic process; and regulation of vascular permeability. Located in several cellular components, including extracellular space; membrane raft; and microvillus. Implicated in brain ischemia; diabetic retinopathy; and hypertension. Biomarker of carcinoma (multiple); hypertension; and ovarian cancer.
Mouse Angpt1 Target Information
- Target Symbol: Angpt1, angiopoietin 1
- Alias:
- 1110046O21Rik
- Ang-1
- ang1
- Angiopoietin-1
- RIKEN cDNA 1110046O21 gene
- NCBI_Gene: 11600
Mouse Angpt1 Predicted Functions
Enables signaling receptor binding activity. Acts upstream of or within several processes, including blood vessel development; regulation of protein phosphorylation; and regulation of signal transduction. Predicted to be located in membrane raft; microvillus; and plasma membrane. Predicted to be active in collagen-containing extracellular matrix and extracellular space. Is expressed in several structures, including cardiovascular system; liver; lung; metanephros; and yolk sac. Human ortholog(s) of this gene implicated in brain ischemia; diabetic retinopathy; and hypertension. Orthologous to human ANGPT1 (angiopoietin 1).
Rat Angpt1 Target Information
- Target Symbol: Angpt1, angiopoietin 1
- Alias:
- Agpt
- Agpt1
- Ang-1
- angiopoietin
- angiopoietin-1
- LOC360422
- NCBI_Gene: 89807
Rat Angpt1 Predicted Functions
Enables identical protein binding activity. Involved in several processes, including animal organ development; response to estrogen; and response to vitamin B3. Located in extracellular space. Biomarker of gastric ulcer; in situ carcinoma; myocardial infarction; nephrosis; and pulmonary hypertension. Human ortholog(s) of this gene implicated in brain ischemia; diabetic retinopathy; and hypertension. Orthologous to human ANGPT1 (angiopoietin 1).
