HGNC ID: 6011
Target Abstract:
Interleukin 3 (IL-3) is encoded by the IL3 gene in humans. It is a biosignal (cytokine) that works as part of the immune system to enhance the body’s innate immune response to disease. It is secreted by basophils and activated T cells and assists in the growth and differentiation of bone marrow-derived T cells in the immune response.IL-3 acts by binding to the IL-3 receptor to stimulate the differentiation of pluripotent hematopoietic stem cells into myeloid progenitors or, together with IL-7, to stimulate the differentiation of pluripotent hematopoietic stem cells into lymphoid progenitors. In addition, IL-3, together with other cytokines such as erythropoietin (EPO), granulocyte macrophage colony-stimulating factor (GM-CSF), and IL-6, stimulates the proliferation of all cells of the myeloid lineage (granulocytes, monocytes, and dendritic cells).
IL3 Target Infomation Overview
- Target Symbol: IL3, interleukin 3
- Gene Groups: Interleukins
- Alias: IL-3; MULTI-CSF; MCGF; MGC79398; MGC79399
- Alias Names: multilineage-colony-stimulating factor; hematopoietic growth factor; P-cell stimulating factor; mast-cell growth factor; colony-stimulating factor, multiple; interleukin 3 (colony-stimulating factor, multiple)
IL3, interleukin 3 Target Infomation by Species
- Human
- Mouse
- Rat
Human IL3 Target Information
- Target Symbol: IL3, interleukin 3
- Alias:
- colony-stimulating factor, multiple
- hematopoietic growth factor
- IL-3
- interleukin-3
- mast cell growth factor
- mast-cell growth factor
- MCGF
- MGC79398
- MGC79399
- MULTI-CSF
- multilineage-colony-stimulating factor
- multipotential colony-stimulating factor
- P-cell stimulating factor
- P-cell-stimulating factor
- NCBI_Gene: 3562
- UniProtKB: P08700
Human IL3 Predicted Functions
Predicted to enable interleukin-3 receptor binding activity. Involved in embryonic hemopoiesis; positive regulation of cell population proliferation; and positive regulation of tyrosine phosphorylation of STAT protein. Predicted to be located in extracellular space. Implicated in Graves’ disease; asthma; and rheumatoid arthritis. Biomarker of several diseases, including Ebola hemorrhagic fever; genital herpes; major depressive disorder; obesity; and psoriasis.
Mouse Il3 Target Information
- Target Symbol: Il3, interleukin 3
- Alias:
- BPA
- colony stimulating factor, multi (contains Il-3)
- Csfmu
- HCGF
- Il-3
- MCGF
- PSF
- NCBI_Gene: 16187
Mouse Il3 Predicted Functions
Enables cytokine activity; growth factor activity; and interleukin-3 receptor binding activity. Acts upstream of or within several processes, including cell surface receptor signaling pathway; monocyte differentiation; and regulation of phosphate metabolic process. Located in extracellular space. Is expressed in skin; stomach; thymus; and vascular system. Human ortholog(s) of this gene implicated in Graves’ disease; asthma; and rheumatoid arthritis. Orthologous to human IL3 (interleukin 3).
Rat Il3 Target Information
- Target Symbol: Il3, interleukin 3
- Alias:
- hematopoietic growth factor
- IL-3
- interleukin-3
- mast cell growth factor
- MCGF
- multipotential colony-stimulating factor
- P-cell-stimulating factor
- NCBI_Gene: 24495
Rat Il3 Predicted Functions
Enables cytokine activity and interleukin-3 receptor binding activity. Involved in several processes, including hemopoiesis; positive regulation of cell population proliferation; and regulation of cell growth. Located in extracellular space. Used to study osteosarcoma. Biomarker of prostatic hypertrophy and pyelonephritis. Human ortholog(s) of this gene implicated in Graves’ disease; asthma; and rheumatoid arthritis. Orthologous to human IL3 (interleukin 3).
