HGNC ID: 18437
Target Abstract:
CD366, also known as TIM-3, is a type I transmembrane glycoprotein belonging to the TIM family within the immunoglobulin superfamily.CD366 is expressed on Th1, Th17, Treg, NK, NK-T, dendritic cells, monocytes, mast cells, and macrophages, but is not expressed on B cells and Th2 cells.CD366 regulates macrophage activation and is a negative regulator of Th1 cell CD366 regulates macrophage activation and is a negative regulator of Th1 cell function.
HAVCR2 Target Infomation Overview
- Target Symbol: HAVCR2, hepatitis A virus cellular receptor 2
- Gene Groups: V-set domain containing
- Alias: Tim-3; TIM3; FLJ14428; TIMD3; CD366
- Alias Names: T-cell immunoglobulin mucin family member 3
HAVCR2, hepatitis A virus cellular receptor 2 Target Infomation by Species
- Human
- Mouse
- Rat
Human HAVCR2 Target Information
- Target Symbol: HAVCR2, hepatitis A virus cellular receptor 2
- Alias:
- CD366
- FLJ14428
- HAVcr-2
- kidney injury molecule-3
- KIM-3
- SPTCL
- T cell immunoglobulin mucin 3
- T cell immunoglobulin mucin-3
- T-cell immunoglobulin and mucin domain-containing protein 3
- T-cell immunoglobulin mucin family member 3
- T-cell immunoglobulin mucin receptor 3
- T-cell membrane protein 3
- Tim-3
- TIM3
- TIMD-3
- TIMD3
- NCBI_Gene: 84868
- UniProtKB: Q8TDQ0
Human HAVCR2 Predicted Functions
Predicted to enable metal ion binding activity. Involved in several processes, including natural killer cell tolerance induction; negative regulation of leukocyte activation; and regulation of cytokine production. Located in cell surface. Implicated in hepatocellular carcinoma and renal cell carcinoma. Biomarker of cystic fibrosis and pulmonary tuberculosis.
Mouse Havcr2 Target Information
- Target Symbol: Havcr2, hepatitis A virus cellular receptor 2
- Alias:
- T-cell immunoglobulin and mucin domain containing 3
- TIM-3
- Tim3
- Timd3
- NCBI_Gene: 171285
Mouse Havcr2 Predicted Functions
Predicted to enable metal ion binding activity. Involved in several processes, including regulation of cytokine production; regulation of leukocyte activation; and toll-like receptor signaling pathway. Located in cell surface; early endosome; and immunological synapse. Is expressed in several structures, including dorsal aorta; gut; liver; lung; and reproductive system. Human ortholog(s) of this gene implicated in hepatocellular carcinoma and renal cell carcinoma. Orthologous to human HAVCR2 (hepatitis A virus cellular receptor 2).
Rat Havcr2 Target Information
- Target Symbol: Havcr2, hepatitis A virus cellular receptor 2
- Alias:
- HAVcr-2
- hepatitis A virus cellular receptor 2 homolog
- LOC363578
- T cell immunoglobulin mucin-3
- T-cell immunoglobulin and mucin domain-containing protein 3
- T-cell immunoglobulin mucin receptor 3
- T-cell membrane protein 3
- TIM-3
- tim3
- TIMD-3
- NCBI_Gene: 363578
- UniProtKB: P0C0K5
Rat Havcr2 Predicted Functions
Predicted to enable metal ion binding activity. Predicted to be involved in several processes, including regulation of cytokine production; regulation of leukocyte activation; and toll-like receptor signaling pathway. Located in cell surface. Biomarker of transient cerebral ischemia. Human ortholog(s) of this gene implicated in hepatocellular carcinoma and renal cell carcinoma. Orthologous to human HAVCR2 (hepatitis A virus cellular receptor 2).