Target Abstract: The common gamma chain ( γ c) (or CD132), also known as interleukin-2 receptor subunit gamma or IL2RG, is a member of the type I cytokine receptor family expressed on most lymphocyte (white blood cell) populations, and its gene is found on the X-chromosome of mammals. The common gamma chain (γc) (or IL2RG), is a cytokine receptor subunit that is common to the receptor complexes for at least six different interleukin receptors: IL-2, IL-4, IL-7, IL-9, IL-15, and the interleukin-21 receptor. It is a component of multiple cytokine receptors that are essential for lymphocyte development and function. X-linked severe combined immunodeficiency (X-SCID) is a rare and potentially fatal disease caused by mutations of IL2RG, the gene encoding IL2RG. IL2RG was demonstrated to be a component of the IL-4 receptor based on chemical cross-linking data, the ability of IL2RG to augment IL-4 binding affinity. The observation that IL-2R gamma is a functional component of the IL-4 receptor, together with the finding that IL-2R gamma associates with the IL-7 receptor, begins to elucidate why a deficiency of this common gamma chain (gamma c) has a profound effect on lymphoid function and development, as seen in X-linked severe combined immunodeficiency.

IL2RG Target Infomation Overview

• Target Symbol: IL2RG, interleukin 2 receptor subunit gamma
• Gene Groups: Interleukin receptors; Fibronectin type III domain containing; CD molecules
• Alias: CD132; SCIDX1; IMD4; CIDX
• Alias Names: severe combined immunodeficiency; combined immunodeficiency, X-linked; interleukin 2 receptor, gamma

IL2RG, interleukin 2 receptor subunit gamma Target Infomation by Species