HGNC ID: 1678
Target Abstract:
CD4, also known as T4, is a 55 kDa single-chain type I transmembrane glycoprotein. It is expressed on most thymocytes, T cell subsets, and monocytes/macrophages. As a member of the immunoglobulin superfamily, CD4 can recognize antigens bound to MHC class II molecules and participate in cell-cell interactions, thymic differentiation, and signal transduction. CD4 serves as the primary receptor for HIV and can bind to HIV gp120. CD4 also interacts with IL-16.
CD4 Target Infomation Overview
- Target Symbol: CD4, CD4 molecule
- Gene Groups: CD molecules; V-set domain containing; C2-set domain containing
- Alias Names: CD4 antigen (p55); T-cell surface glycoprotein CD4
CD4, CD4 molecule Target Infomation by Species
- Human
- Mouse
- Rat
Human CD4 Target Information
- Target Symbol: CD4, CD4 molecule
- Alias:
- cd4 antigen
- CD4 antigen (p55)
- CD4 receptor
- CD4mut
- IMD79
- OKT4D
- T-cell surface antigen T4/Leu-3
- T-cell surface glycoprotein CD4
- NCBI_Gene: 920
- UniProtKB: P01730
Human CD4 Predicted Functions
Enables several functions, including interleukin-16 binding activity; interleukin-16 receptor activity; and protein homodimerization activity. Involved in several processes, including cellular response to cytokine stimulus; leukocyte differentiation; and positive regulation of intracellular signal transduction. Acts upstream of or within maintenance of protein location in cell. Located in external side of plasma membrane and membrane raft. Is integral component of plasma membrane. Implicated in immunodeficiency 79. Biomarker of COVID-19 and severe acute respiratory syndrome.
Mouse Cd4 Target Information
- Target Symbol: Cd4, CD4 antigen
- Alias:
- L3T4
- Ly-4
- lymphocyte antigen 4
- NCBI_Gene: 12504
Mouse Cd4 Predicted Functions
Predicted to enable several functions, including interleukin-16 binding activity; interleukin-16 receptor activity; and protein homodimerization activity. Involved in helper T cell enhancement of adaptive immune response. Acts upstream of or within several processes, including defense response to Gram-negative bacterium; positive regulation of calcium-mediated signaling; and positive regulation of peptidyl-tyrosine phosphorylation. Located in endoplasmic reticulum; external side of plasma membrane; and membrane raft. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system; and liver and biliary system. Used to study type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in immunodeficiency 79. Orthologous to human CD4 (CD4 molecule).
Rat Cd4 Target Information
- Target Symbol: Cd4, Cd4 molecule
- Alias:
- CD4 antigen
- CD4 antigen (p55)
- p55
- T-cell surface antigen T4/Leu-3
- T-cell surface glycoprotein CD4
- W3/25
- W3/25 antigen
- NCBI_Gene: 24932
- UniProtKB: P05540
Rat Cd4 Predicted Functions
Enables immunoglobulin binding activity; protein tyrosine kinase binding activity; and signaling receptor binding activity. Involved in several processes, including positive regulation of calcium ion transport into cytosol; response to estradiol; and response to vitamin D. Located in external side of plasma membrane. Used to study septic arthritis and sialadenitis. Human ortholog(s) of this gene implicated in immunodeficiency 79. Orthologous to human CD4 (CD4 molecule).