HGNC ID: 10803
Target Abstract:
Surface-active protein D (SP-D) has a molecular weight of 43 kDa and is a member of the collagen lectin family with innate immunomodulatory properties. It is constitutively secreted by alveolar lining cells and epithelial cells associated with tubular structures and is induced in cardiac smooth muscle and endothelial cells. Human SP-D is present in serum, plasma, bronchoalveolar lavage fluid, and amniotic fluid.SP-D plays an important role in organismal defense and innate immunity.SP-D binds to neutrophil defensins and regulates antiviral defense. Current studies have shown that SP-D is involved in the development and progression of a variety of lung diseases and may serve as a biomarker for these diseases.
SFTPD Target Infomation Overview
- Target Symbol: SFTPD, surfactant protein D
- Gene Groups: Collectins; C-type lectin domain containing
- Alias: SP-D; COLEC7
- Previous Names: SFTP4
- Alias Names: surfactant, pulmonary-associated protein D
SFTPD, surfactant protein D Target Infomation by Species
- Human
- Mouse
- Rat
Human SFTPD Target Information
- Target Symbol: SFTPD, surfactant protein D
- Alias:
- COLEC7
- collectin 7
- collectin-7
- lung surfactant protein D
- PSP-D
- pulmonary surfactant apoprotein
- pulmonary surfactant-associated protein D
- SFTP4
- SP-D
- surfactant-associated protein, pulmonary 4
- surfactant, pulmonary-associated protein D
- NCBI_Gene: 6441
- UniProtKB: P35247
Human SFTPD Predicted Functions
Predicted to enable identical protein binding activity. Involved in several processes, including induction of bacterial agglutination; negative regulation by host of symbiont catalytic activity; and surfactant homeostasis. Predicted to be located in cytoplasm. Predicted to be part of collagen trimer. Predicted to be active in extracellular space; multivesicular body; and rough endoplasmic reticulum. Implicated in asthma; lung disease (multiple); respiratory syncytial virus infectious disease; and rhinitis. Biomarker of several diseases, including cystic fibrosis; lung disease (multiple); respiratory syncytial virus infectious disease; sarcoidosis; and systemic lupus erythematosus.
Mouse Sftpd Target Information
- Target Symbol: Sftpd, surfactant associated protein D
- Alias:
- AI573415
- expressed sequence AI573415
- Sfpd
- Sftp4
- SP-D
- surfactant-associated protein 4
- NCBI_Gene: 20390
Mouse Sftpd Predicted Functions
Enables identical protein binding activity. Predicted to be involved in several processes, including induction of bacterial agglutination; negative regulation of interleukin-2 production; and regulation of phagocytosis. Predicted to act upstream of or within innate immune response and respiratory gaseous exchange by respiratory system. Located in cytoplasm. Is expressed in lung; otic capsule; and skeleton. Human ortholog(s) of this gene implicated in asthma; lung disease (multiple); respiratory syncytial virus infectious disease; and rhinitis. Orthologous to human SFTPD (surfactant protein D).
Rat Sftpd Target Information
- Target Symbol: Sftpd, surfactant protein D
- Alias:
- CP4
- lung surfactant protein D
- PSP-D
- pulmonary surfactant protein D
- pulmonary surfactant-associated protein D
- SP-D
- SPD
- surfactant associated protein D
- surfactant pulmonary-associated protein D
- surfactant, pulmonary-associated protein D
- NCBI_Gene: 25350
Rat Sftpd Predicted Functions
Enables identical protein binding activity; lipopolysaccharide binding activity; and monosaccharide binding activity. Involved in several processes, including negative regulation of interleukin-2 production; opsonization; and regulation of phagocytosis. Located in extracellular space; multivesicular body; and rough endoplasmic reticulum. Biomarker of Coronavirus infectious disease; asthma; bacterial pneumonia; lung disease; and newborn respiratory distress syndrome. Human ortholog(s) of this gene implicated in asthma; lung disease (multiple); respiratory syncytial virus infectious disease; and rhinitis. Orthologous to human SFTPD (surfactant protein D).
