HGNC ID: 5473
Target Abstract:
Insulin-like growth factor binding protein 4 (IGFBP4) is a 24 kDa protein that binds insulin-like growth factors (IGFs) I and II and circulates in plasma in both glycosylated and non-glycosylated forms. This binding extends the half-life of the IGFs and alters their interaction with cell surface receptors. The superfamily of insulin-like growth factor (IGF)-binding proteins consists of six high-affinity IGF-binding proteins (IGFBPs) and at least four low-affinity binding proteins known as IGFBP-associated proteins (IGFBP-RPs.) IGFBP-4 inhibits the action of IGF-I in vitro, and it is the most abundant IGF-binding protein in the arterial wall of rodents. In nontransgenic littermates, IGFBP4 mRNA expression was highest in the liver and kidney.
IGFBP4 Target Infomation Overview
- Target Symbol: IGFBP4, insulin like growth factor binding protein 4
- Gene Groups: Insulin like growth factor binding proteins
- Alias: IBP4; BP-4; HT29-IGFBP; IGFBP-4
- Alias Names: IGF-binding protein 4; insulin-like growth factor-binding protein 4; insulin-like growth factor binding protein 4
IGFBP4, insulin like growth factor binding protein 4 Target Infomation by Species
- Human
- Mouse
- Rat
Human IGFBP4 Target Information
- Target Symbol: IGFBP4, insulin like growth factor binding protein 4
- Alias:
- BP-4
- HT29-IGFBP
- IBP-4
- IBP4
- IGF-binding protein 4
- IGFBP-4
- insulin-like growth factor binding protein 4
- insulin-like growth factor-binding protein 4
- NCBI_Gene: 3487
- UniProtKB: P22692
Human IGFBP4 Predicted Functions
Predicted to enable insulin-like growth factor I binding activity and insulin-like growth factor II binding activity. Predicted to be involved in regulation of insulin-like growth factor receptor signaling pathway. Predicted to act upstream of or within several processes, including positive regulation of signal transduction; regulation of glucose metabolic process; and type B pancreatic cell proliferation. Predicted to be located in endoplasmic reticulum lumen and extracellular region. Predicted to be active in extracellular space.
Mouse Igfbp4 Target Information
- Target Symbol: Igfbp4, insulin-like growth factor binding protein 4
- Alias:
- AI875747
- Band 3A
- Deb2
- differentially expressed in B16F10 2
- expressed sequence AI875747
- IGFBP-4
- NCBI_Gene: 16010
Mouse Igfbp4 Predicted Functions
Enables insulin-like growth factor binding activity. Acts upstream of or within several processes, including positive regulation of signal transduction; regulation of glucose metabolic process; and type B pancreatic cell proliferation. Located in extracellular space. Is expressed in several structures, including alimentary system; early embryo; female reproductive system; limb; and lung. Orthologous to human IGFBP4 (insulin like growth factor binding protein 4).
Rat Igfbp4 Target Information
- Target Symbol: Igfbp4, insulin-like growth factor binding protein 4
- Alias:
- IBP-4
- IBP4
- IGF-binding protein 4
- IGF-BP4
- IGFBP-4
- insulin-like growth factor-binding protein 4
- NCBI_Gene: 360622
- UniProtKB: P21744
Rat Igfbp4 Predicted Functions
Predicted to enable insulin-like growth factor I binding activity and insulin-like growth factor II binding activity. Involved in inflammatory response. Predicted to be active in extracellular space. Orthologous to human IGFBP4 (insulin like growth factor binding protein 4).
