Glucagon is produced by the pancreas α A peptide hormone produced by cells, consisting of 29 amino acids with a molecular weight of 3485 Da, plays a crucial role in glucose metabolism and homeostasis. The function of glucagon is to increase the concentration of glucose in the blood, and it is also used as a medication to treat some health conditions. It is opposite to the insulin effect of reducing glucose. When the glucose concentration in the blood is too low, the pancreas releases glucagon. Glucagon converts the stored glycogen in the liver into glucose, which is then released into the bloodstream. On the other hand, high blood sugar levels stimulate insulin release. Glucagon promotes the absorption and consumption of glucose by insulin dependent tissues, therefore, glucagon and insulin are part of the feedback system that maintains stable blood sugar levels. Abnormal elevation of glucagon may be caused by pancreatic tumors, such as glucagon tumors, characterized by necrolytic erythema, low amino acids, and high blood sugar. This phenomenon can occur alone or in a type I environment with multiple endocrine tumors.