HGNC ID: 3009
Target Abstract:
Dipeptidyl peptidase IV (DPPIV), also known as adenosine deaminase complex protein 2 or CD26, is an antigenic enzyme expressed on the surface of most cell types, associated with immune regulation, signal transduction, and cell apoptosis. It is a congenital membrane glycoprotein and serine exopeptidase. DPPIV plays an important role in glucose metabolism, responsible for the degradation of intestinal proinsulin such as GLP-1. In addition, it can also inhibit the development of cancer and tumors. Animal experiments have shown that it plays a pathogenic role in the development of fibrosis in many organs such as the liver and kidneys. DPPIV plays an important role in tumor biology and is an effective biomarker for various cancers. Its levels increase on the cell surface or serum of some tumors and decrease in other tumors. Middle East Respiratory Syndrome Coronavirus, a new coronavirus associated with SARS, has been found to bind to DPPIV. DPPIV exists on the surface of cells in the airways (such as lungs) and kidneys, and scientists use their advantage to block virus entry into cells.
DPP4 Target Infomation Overview
- Target Symbol: DPP4, dipeptidyl peptidase 4
- Gene Groups: CD molecules; DASH family
- Alias: DPPIV
- Previous Names: CD26; ADCP2
- Alias Names: dipeptidylpeptidase IV (CD26, adenosine deaminase complexing protein 2); adenosine deaminase complexing protein 2; dipeptidyl-peptidase 4
DPP4, dipeptidyl peptidase 4 Target Infomation by Species
- Human
- Mouse
- Rat
Human DPP4 Target Information
- Target Symbol: DPP4, dipeptidyl peptidase 4
- Alias:
- ADABP
- ADCP-2
- ADCP2
- adenosine deaminase complexing protein 2
- CD26
- dipeptidyl peptidase IV
- dipeptidyl-peptidase 4
- dipeptidyl-peptidase 4 (CD26, adenosine deaminase complexing protein 2)
- dipeptidylpeptidase 4
- dipeptidylpeptidase IV (CD26, adenosine deaminase complexing protein 2)
- DPP IV
- DPPIV
- Gly-Pro naphthylamidase
- Post-proline dipeptidyl aminopeptidase IV
- T-cell activation antigen CD26
- TP103
- Xaa-Pro-dipeptidylaminopeptidase
- NCBI_Gene: 1803
- UniProtKB: P27487
Human DPP4 Predicted Functions
Enables several functions, including chemorepellent activity; peptidase activity; and protein homodimerization activity. Involved in several processes, including negative regulation of extracellular matrix disassembly; negative regulation of neutrophil chemotaxis; and regulation of cell-cell adhesion. Located in several cellular components, including apical plasma membrane; endocytic vesicle; and lamellipodium. Implicated in Middle East respiratory syndrome and type 2 diabetes mellitus.
Mouse Dpp4 Target Information
- Target Symbol: Dpp4, dipeptidylpeptidase 4
- Alias:
- Cd26
- CD26 antigen
- Dpp-4
- THAM
- NCBI_Gene: 13482
Mouse Dpp4 Predicted Functions
Predicted to enable several functions, including chemorepellent activity; peptidase activity; and protein homodimerization activity. Acts upstream of or within behavioral fear response; locomotory exploration behavior; and psychomotor behavior. Located in intercellular canaliculus. Is expressed in several structures, including genitourinary system; inner ear; intraembryonic coelom; liver; and primitive heart tube. Used to study Middle East respiratory syndrome. Human ortholog(s) of this gene implicated in Middle East respiratory syndrome and type 2 diabetes mellitus. Orthologous to human DPP4 (dipeptidyl peptidase 4).
Rat Dpp4 Target Information
- Target Symbol: Dpp4, dipeptidylpeptidase 4
- Alias:
- bile canaliculus domain-specific membrane glycoprotein
- CD26
- Dipeptidyl peptidase 4
- dipeptidyl peptidase IV
- DPP IV
- DPPIV
- GP110 glycoprotein
- T-cell activation antigen CD26
- NCBI_Gene: 25253
Rat Dpp4 Predicted Functions
Enables several functions, including collagen binding activity; dipeptidyl-peptidase activity; and identical protein binding activity. Involved in several processes, including B-1a B cell differentiation; proteolysis; and regulation of lymphocyte mediated immunity. Located in several cellular components, including Golgi apparatus; cell surface; and endoplasmic reticulum. Human ortholog(s) of this gene implicated in Middle East respiratory syndrome and type 2 diabetes mellitus. Orthologous to human DPP4 (dipeptidyl peptidase 4).
