HGNC ID: 4603
Target Abstract:
Human growth-regulated oncogene beta (GRO-β), also known as CXCL2, is a member of the CXC family of protein chemokines.GRO-β is also known as MIP-2 in mice and CINC-3 in rats.GRO-β consists of 107 amino acids (aa) and has a molecular weight of approximately 11 kDa.GRO-β is secreted by a variety of cells at the site of inflammation, including monocytes and macrophages, and has chemotactic effects on granulocytes, including neutrophils. GRO-β is secreted by a variety of cells at the site of inflammation, including monocytes and macrophages, and has a chemotactic effect on granulocytes, including neutrophils.GRO-β plays an important role in inflammatory response and damage repair. GRO has been gradually identified as a proto-oncogene, and its expression plays a key role in angiogenesis, metastasis, and tumor-immune cell interactions.
CXCL2 Target Infomation Overview
- Target Symbol: CXCL2, C-X-C motif chemokine ligand 2
- Gene Groups: Chemokine ligands
- Alias: SCYB2; GROb; MIP-2a; MGSA-b; CINC-2a
- Previous Names: GRO2
- Alias Names: GRO2 oncogene; chemokine (C-X-C motif) ligand 2
CXCL2, C-X-C motif chemokine ligand 2 Target Infomation by Species
- Human
- Mouse
- Rat
Human CXCL2 Target Information
- Target Symbol: CXCL2, C-X-C motif chemokine ligand 2
- Alias:
- C-X-C motif chemokine 2
- chemokine (C-X-C motif) ligand 2
- CINC-2a
- gro-beta
- GRO2
- GRO2 oncogene
- GROb
- growth-regulated protein beta
- macrophage inflammatory protein 2-alpha
- melanoma growth stimulatory activity beta
- MGSA beta
- MGSA-b
- MIP-2a
- MIP2
- MIP2-alpha
- MIP2A
- SCYB2
- NCBI_Gene: 2920
- UniProtKB: P19875
Human CXCL2 Predicted Functions
Predicted to enable CXCR chemokine receptor binding activity and chemokine activity. Involved in antimicrobial humoral immune response mediated by antimicrobial peptide; killing of cells of other organism; and response to molecule of bacterial origin. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Biomarker of COVID-19 and cystic fibrosis.
Mouse Cxcl2 Target Information
- Target Symbol: Cxcl2, chemokine (C-X-C motif) ligand 2
- Alias:
- CINC-2a
- Gro2
- GROb
- macrophage inflammatory protein 2
- Mgsa-b
- MIP-2
- MIP-2a
- Mip2
- Scyb
- Scyb2
- small inducible cytokine B subfamily
- small inducible cytokine subfamily, member 2
- NCBI_Gene: 20310
Mouse Cxcl2 Predicted Functions
Predicted to enable CXCR chemokine receptor binding activity and chemokine activity. Involved in response to molecule of bacterial origin. Located in extracellular space. Is expressed in several structures, including alimentary system; embryo mesenchyme; floor plate; respiratory system; and skin. Orthologous to several human genes including CXCL3 (C-X-C motif chemokine ligand 3).
Rat Cxcl2 Target Information
- Target Symbol: Cxcl2, C-X-C motif chemokine ligand 2
- Alias:
- C-X-C motif chemokine 2
- chemokine (C-X-C motif) ligand 2
- CINC-3
- cytokine-induced neutrophil chemoattractant 3
- macrophage inflammatory protein 2
- Mip-2
- MIP2
- Scyb2
- small inducible cytokine subfamily member 2
- small inducible cytokine subfamily, member 2
- NCBI_Gene: 114105
- UniProtKB: P30348
Rat Cxcl2 Predicted Functions
Enables chemokine activity. Involved in several processes, including cellular response to interleukin-1; cellular response to lipopolysaccharide; and neutrophil chemotaxis. Located in extracellular space. Biomarker of several diseases, including acute necrotizing pancreatitis; bile duct disease (multiple); brain edema; pleurisy; and pneumonia (multiple). Orthologous to human CXCL2 (C-X-C motif chemokine ligand 2).
