HGNC ID: 5471
Target Abstract:
Insulin-like growth factor binding proteins (IGFBPs) play an essential role in modifying the action of insulin-like growth factor (IGF) in many cell types. There are six structurally related but genetically distinct members of this family. IGFBP2 is the second most abundant circulating IGFBP and is found in other biofluids and tissues in many vertebrates. Serum IGFBP2 levels are elevated in response to shock, fasting, hypoxemia, or post-traumatic injury, suggesting complex regulation of IGFBP2 expression. IGFBP2 is overexpressed in many malignant tumors and correlates with tumor malignancy, suggesting that IGFBP2 may be involved in tumorigenesis. During development, IGFBP-2 is expressed in several tissues. The highest level of expression is found in the central nervous system (CNS). It is also highly expressed in the adult CNS and many reproductive tissues.
IGFBP2 Target Infomation Overview
- Target Symbol: IGFBP2, insulin like growth factor binding protein 2
- Gene Groups: Insulin like growth factor binding proteins
- Previous Names: IBP2
- Alias Names: insulin-like growth factor binding protein 2 (36kD); insulin-like growth factor binding protein 2, 36kDa; insulin-like growth factor binding protein 2
IGFBP2, insulin like growth factor binding protein 2 Target Infomation by Species
- Human
- Mouse
- Rat
Human IGFBP2 Target Information
- Target Symbol: IGFBP2, insulin like growth factor binding protein 2
- Alias:
- IBP-2
- IBP2
- IGF-binding protein 2
- IGF-BP53
- IGFBP-2
- insulin-like growth factor binding protein 2
- insulin-like growth factor binding protein 2, 36kDa
- insulin-like growth factor-binding protein 2
- NCBI_Gene: 3485
- UniProtKB: P18065
Human IGFBP2 Predicted Functions
Enables insulin-like growth factor I binding activity. Involved in positive regulation of activated T cell proliferation. Located in extracellular space. Implicated in obesity. Biomarker of Alzheimer’s disease; Kuhnt-Junius degeneration; and obesity.
Mouse Igfbp2 Target Information
- Target Symbol: Igfbp2, insulin-like growth factor binding protein 2
- Alias:
- AI255832
- expressed sequence AI255832
- IGFBP-2
- Igfbp-2
- NCBI_Gene: 16008
Mouse Igfbp2 Predicted Functions
Enables insulin-like growth factor binding activity. Predicted to be involved in positive regulation of activated T cell proliferation and regulation of insulin-like growth factor receptor signaling pathway. Predicted to act upstream of or within regulation of growth. Located in extracellular space. Is expressed in several structures, including brain; early embryo; limb; metanephros; and reproductive system. Human ortholog(s) of this gene implicated in obesity. Orthologous to human IGFBP2 (insulin like growth factor binding protein 2).
Rat Igfbp2 Target Information
- Target Symbol: Igfbp2, insulin-like growth factor binding protein 2
- Alias:
- BRL-BP
- IBP-2
- IGF-binding protein 2
- IGFBP-2
- ILGFBPA
- insulin-like growth factor-binding protein 2
- NCBI_Gene: 25662
- UniProtKB: P12843
Rat Igfbp2 Predicted Functions
Enables insulin-like growth factor I binding activity and insulin-like growth factor II binding activity. Involved in several processes, including response to estradiol; response to estrogen; and response to retinoic acid. Located in apical plasma membrane; cytoplasmic vesicle; and extracellular space. Biomarker of hypertension and hypothyroidism. Human ortholog(s) of this gene implicated in obesity. Orthologous to human IGFBP2 (insulin like growth factor binding protein 2).
