Target Abstract: Coagulation factor VII, also known as Serum prothrombin conversion accelerator, Factor VII, F7 and FVII, is a member of the peptidase S1 family. Factor VII is one of the central proteins in the coagulation cascade. It is an enzyme of the serine protease class, and Factor VII (FVII) deficiency is the most frequent among rare congenital bleeding disorders. Factor VII contains two EGF-like domains, one Gla (gamma-carboxy-glutamate) domain and one peptidase S1 domain. The main role of factor VII is to initiate the process of coagulation in conjunction with tissue factor (TF). Tissue factor is found on the outside of blood vessels, normally not exposed to the blood stream. The action of the Factor VII is impeded by tissue factor pathway inhibitor (TFPI), which is released almost immediately after initiation of coagulation. Factor VII is vitamin K dependent and is produced in the liver. Upon vessel injury, tissue factor is exposed to the blood and circulating Factor VII. Once bound to TF, FVII is activated to FVIIa by different proteases, among which are thrombin (factor IIa), factor Xa, IXa, XIIa, and the FVIIa-TF complex itself.
F7 Target Infomation Overview
- Target Symbol: F7, coagulation factor VII
- Gene Groups: Gla domain containing
- Alias: eptacog alfa; FVII coagulation protein; factor VII, coagulation factor VII (serum prothrombin conversion accelerator)
F7, coagulation factor VII Target Infomation by Species
- Human
- Mouse
- Rat
Human F7 Target Information
- Target Symbol: F7, coagulation factor VII
- Alias:
- coagulation factor VII (serum prothrombin conversion accelerator)
- eptacog alfa
- FVII coagulation protein
- FVIIa
- proconvertin
- serum prothrombin conversion accelerator
- SPCA
- NCBI_Gene: 2155
- UniProtKB: P08709
Human F7 Predicted Functions
Contributes to serine-type endopeptidase activity. Involved in several processes, including blood coagulation; positive regulation of chemotaxis; and positive regulation of signal transduction. Located in collagen-containing extracellular matrix. Part of serine-type peptidase complex. Implicated in several diseases, including artery disease (multiple); cerebral infarction; diabetes mellitus (multiple); factor VII deficiency; and obesity. Biomarker of several diseases, including angioedema (multiple); artery disease (multiple); diabetic neuropathy; glucose metabolism disease (multiple); and kidney disease (multiple).
Mouse F7 Target Information
- Target Symbol: F7, coagulation factor VII
- Alias:
- AI132620
- Cf7
- expressed sequence AI132620
- FVII
- NCBI_Gene: 14068
Mouse F7 Predicted Functions
Predicted to enable serine-type endopeptidase activity and signaling receptor binding activity. Acts upstream of or within blood coagulation. Predicted to be located in vesicle. Predicted to be part of serine-type peptidase complex. Predicted to be active in extracellular space. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and liver and biliary system. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); cerebral infarction; diabetes mellitus (multiple); factor VII deficiency; and obesity. Orthologous to human F7 (coagulation factor VII).
Rat F7 Target Information
- Target Symbol: F7, coagulation factor VII
- Alias:
- coagulation factor VII (serum prothrombin conversion accelerator)
- serum prothrombin conversion accelerator
- NCBI_Gene: 260320
Rat F7 Predicted Functions
Enables endopeptidase activity and signaling receptor binding activity. Involved in several processes, including response to growth hormone; response to thyrotropin-releasing hormone; and response to thyroxine. Located in extracellular space and vesicle. Used to study asthma; diabetes mellitus; and type 2 diabetes mellitus. Biomarker of several diseases, including bilirubin metabolic disorder; familial hyperlipidemia; hypertension; hypothyroidism; and prothrombin deficiency. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); cerebral infarction; diabetes mellitus (multiple); factor VII deficiency; and obesity. Orthologous to human F7 (coagulation factor VII).
