HGNC ID: 9446
Target Abstract:
Prolactin receptor (PRLR) is a cytokine receptor, encoded by a gene located on chromosome 5p13-14, that interacts with prolactin as a transmembrane receptor.PRLR consists of an extracellular region, a transmembrane region, and a cytoplasmic region that binds prolactin.PRLR is widely expressed in mammary glands, placentas, kidneys, livers, and pancreases, and, in addition to prolactin, it is also activated by growth hormone (GH) and human placental lactogen (hPL) activation. Studies have shown that abnormalities in PRLR are closely associated with the development and prognosis of certain tumors, especially breast cancer. Specific binding to PRLR stimulates breast cancer cell growth, and antagonists that bind to PRLR but do not dimerize it inhibit breast cancer cell growth.Several isoforms of PRLR exist, including soluble PRLR, which does not transduce prolactin signaling.
PRLR Target Infomation Overview
- Target Symbol: PRLR, prolactin receptor
PRLR, prolactin receptor Target Infomation by Species
- Human
- Mouse
- Rat
Human PRLR Target Information
- Target Symbol: PRLR, prolactin receptor
- Alias:
- delta 4-delta 7/11 truncated prolactin receptor
- delta 4-SF1b truncated prolactin receptor
- HPRL
- hPRL receptor
- hPRLrI
- MFAB
- PRL-R
- prolactin receptor delta 7/11
- RI-PRLR
- secreted prolactin binding protein
- NCBI_Gene: 5618
- UniProtKB: P16471
Human PRLR Predicted Functions
Enables peptide hormone binding activity and prolactin receptor activity. Involved in activation of Janus kinase activity; activation of transmembrane receptor protein tyrosine kinase activity; and negative regulation of apoptotic process. Located in cell surface. Implicated in hyperprolactinemia.
Mouse Prlr Target Information
- Target Symbol: Prlr, prolactin receptor
- Alias:
- AI987712
- expressed sequence AI987712
- Pr-1
- Pr-3
- Prlr-rs1
- prolactin receptor 1
- prolactin receptor 3
- prolactin receptor related sequence 1
- NCBI_Gene: 19116
Mouse Prlr Predicted Functions
Enables prolactin receptor activity. Involved in positive regulation of cold-induced thermogenesis. Acts upstream of or within several processes, including gland development; receptor signaling pathway via JAK-STAT; and response to bacterium. Predicted to be located in cell surface. Predicted to be part of receptor complex. Predicted to be active in external side of plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; hemolymphoid system gland; and limb segment. Used to study familial medullary thyroid carcinoma. Human ortholog(s) of this gene implicated in hyperprolactinemia. Orthologous to human PRLR (prolactin receptor).
Rat Prlr Target Information
- Target Symbol: Prlr, prolactin receptor
- Alias:
- lactogen receptor
- MGC105486
- PRL-R
- RATPRLR
- NCBI_Gene: 24684
Rat Prlr Predicted Functions
Enables prolactin receptor activity and protein kinase binding activity. Predicted to be involved in several processes, including activation of protein kinase activity; cytokine-mediated signaling pathway; and positive regulation of cold-induced thermogenesis. Predicted to act upstream of or within several processes, including gland development; receptor signaling pathway via JAK-STAT; and response to bacterium. Predicted to be located in cell surface. Predicted to be part of receptor complex. Predicted to be active in external side of plasma membrane. Human ortholog(s) of this gene implicated in hyperprolactinemia. Orthologous to human PRLR (prolactin receptor).
