HGNC ID: 5472
Target Abstract:
Insulin-like growth factor-binding protein 3 (IGFBP-3), in humans, is encoded by the IGFBP3 gene.IGFBP-3 is one of six IGF-binding proteins (IGFBP-1 to 6) that have a highly conserved structure and bind with high affinity to IGF-1 and IGF-2.IGFBP-3 is the major transporter protein of IGF in the blood. It interacts with cell surface proteins to influence extracellular or post-internalized cellular signals, and it can also enter the nucleus where it binds nuclear hormone receptors and other ligands. Based on cell growth experiments, animal cancer models and epidemiological studies, IGFBP-3 appears to act as a tumor suppressor gene with low epistasis. Dysregulated IGFBP-3 is involved in many cancers. Serum levels of IGFBP-3 can be used to screen for growth hormone deficiency. IGFBP-3 levels are decreased in the serum of patients with AIDS, uncontrolled diabetes, trauma and severe burns.
IGFBP3 Target Infomation Overview
- Target Symbol: IGFBP3, insulin like growth factor binding protein 3
- Gene Groups: Insulin like growth factor binding proteins
- Alias: IBP3; BP-53
- Alias Names: growth hormone-dependent binding protein; acid stable subunit of the 140 K IGF complex; binding protein 53; binding protein 29; IGF-binding protein 3; insulin-like growth factor binding protein 3
IGFBP3, insulin like growth factor binding protein 3 Target Infomation by Species
- Human
- Mouse
- Rat
Human IGFBP3 Target Information
- Target Symbol: IGFBP3, insulin like growth factor binding protein 3
- Alias:
- acid stable subunit of the 140 K IGF complex
- binding protein 29
- binding protein 53
- BP-53
- growth hormone-dependent binding protein
- IBP-3
- IBP3
- IGF-binding protein 3
- IGFBP-3
- insulin-like growth factor binding protein 3
- insulin-like growth factor-binding protein 3
- NCBI_Gene: 3486
- UniProtKB: P17936
Human IGFBP3 Predicted Functions
Enables insulin-like growth factor I binding activity and protein tyrosine phosphatase activator activity. Involved in several processes, including negative regulation of smooth muscle cell migration; negative regulation of smooth muscle cell proliferation; and positive regulation of myoblast differentiation. Acts upstream of or within negative regulation of cell population proliferation; negative regulation of protein phosphorylation; and protein phosphorylation. Located in extracellular space and nucleus. Part of insulin-like growth factor ternary complex. Implicated in several diseases, including Alzheimer’s disease; Turner syndrome; diabetes mellitus (multiple); prostate cancer; and transitional cell carcinoma. Biomarker of several diseases, including Barrett’s esophagus; Down syndrome; autoimmune disease (multiple); bone disease (multiple); and urinary system cancer (multiple).
Mouse Igfbp3 Target Information
- Target Symbol: Igfbp3, insulin-like growth factor binding protein 3
- Alias:
- AI649005
- expressed sequence AI649005
- IGFBP-3
- NCBI_Gene: 16009
Mouse Igfbp3 Predicted Functions
Enables fibronectin binding activity and insulin-like growth factor binding activity. Acts upstream of or within several processes, including osteoblast differentiation; positive regulation of signal transduction; and type B pancreatic cell proliferation. Located in extracellular space. Is expressed in several structures, including alimentary system; brain; early embryo; gonad; and limb. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer’s disease; Turner syndrome; diabetes mellitus (multiple); prostate cancer; and transitional cell carcinoma. Orthologous to human IGFBP3 (insulin like growth factor binding protein 3).
Rat Igfbp3 Target Information
- Target Symbol: Igfbp3, insulin-like growth factor binding protein 3
- Alias:
- IBP-3
- IGF-binding protein 3
- IGF-BP3
- IGFBP-3
- Insulin-like growth factor-binding protein (IGF-BP3)
- insulin-like growth factor-binding protein 3
- MGC156773
- NCBI_Gene: 24484
Rat Igfbp3 Predicted Functions
Enables insulin-like growth factor II binding activity. Involved in several processes, including cellular response to Thyroglobulin triiodothyronine; cellular response to estradiol stimulus; and response to peptide hormone. Located in extracellular space; heterochromatin; and platelet alpha granule. Part of insulin-like growth factor binary complex and insulin-like growth factor ternary complex. Used to study impotence. Biomarker of congenital diaphragmatic hernia; impotence; and obesity. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer’s disease; Turner syndrome; diabetes mellitus (multiple); prostate cancer; and transitional cell carcinoma. Orthologous to human IGFBP3 (insulin like growth factor binding protein 3).
