HGNC ID: 6152
Target Abstract:
CD11c, known as complement receptor (CR4), is a member of the CD11/CD18 family of adhesion molecules, a type I transmembrane glycoprotein, and is highly expressed on the surface of myeloid DCs.CD11c acts as a positive regulator, participating in the adhesion and migration of DCs, the recognition and presentation of antigens, and the activation of CD4+ and CD8+ T cells. cells, regulating the immune response and playing an important role in infection and anti-tumor immunity.
ITGAX Target Infomation Overview
- Target Symbol: ITGAX, integrin subunit alpha X
- Gene Groups: CD molecules; Integrin alpha subunits; Complement system regulators and receptors
- Alias: CD11c
- Previous Names: CD11C
- Alias Names: complement component 3 receptor 4 subunit; integrin, alpha X (antigen CD11C (p150), alpha polypeptide); integrin, alpha X (complement component 3 receptor 4 subunit)
ITGAX, integrin subunit alpha X Target Infomation by Species
Human
Mouse
Rat
Human ITGAX Target Information
- Target Symbol: ITGAX, integrin subunit alpha X
- Alias:
- CD11 antigen-like family member C
- CD11C
- complement component 3 receptor 4 subunit
- integrin alpha X
- integrin alpha-X
- integrin, alpha X (antigen CD11C (p150), alpha polypeptide)
- integrin, alpha X (complement component 3 receptor 4 subunit)
- leu M5, alpha subunit
- leukocyte adhesion glycoprotein p150,95 alpha chain
- leukocyte adhesion receptor p150,95
- leukocyte surface antigen p150,95, alpha subunit
- myeloid membrane antigen, alpha subunit
- p150 95 integrin alpha chain
- SLEB6
- NCBI_Gene: 3687
- UniProtKB: P20702
Human ITGAX Predicted Functions
Enables receptor tyrosine kinase binding activity. Involved in several processes, including heterotypic cell-cell adhesion; positive regulation of angiogenesis; and positive regulation of endothelial tube morphogenesis. Located in cell surface.
Mouse Itgax Target Information
- Target Symbol: Itgax, integrin alpha X
- Alias:
- AI449405
- Cd11c
- CD11C (p150) alpha polypeptide
- expressed sequence AI449405
- NCBI_Gene: 16411
Mouse Itgax Predicted Functions
Predicted to enable receptor tyrosine kinase binding activity. Involved in positive regulation of gene expression and positive regulation of myelination. Acts upstream of or within defense response to virus. Located in external side of plasma membrane. Is expressed in heart and hemolymphoid system. Orthologous to human ITGAX (integrin subunit alpha X).
Rat Itgax Target Information
- Target Symbol: Itgax, integrin subunit alpha X
- Alias:
- integrin alpha X
- integrin alpha-X
- NCBI_Gene: 499271
- UniProtKB: D3ZWZ1
Rat Itgax Predicted Functions
Predicted to enable receptor tyrosine kinase binding activity. Predicted to be involved in several processes, including positive regulation of angiogenesis; positive regulation of endothelial tube morphogenesis; and positive regulation of myelination. Predicted to act upstream of or within defense response to virus. Predicted to be located in external side of plasma membrane. Predicted to be part of integrin complex. Orthologous to human ITGAX (integrin subunit alpha X).