HGNC ID: 6018
Target Abstract:
Interleukin 6 (IL-6) is a cytokine with both pro-inflammatory and anti-inflammatory properties. In humans, it is encoded by the IL-6 gene. IL-6 is secreted by T cells and macrophages to promote immune response during infection and after trauma, especially inflammation resulting from burns or other tissue damage. Studies have shown that IL-6 is required for mice to resist Streptococcus pneumoniae infection, suggesting a role for IL-6 in fighting infection.IL-6 promotes inflammatory and autoimmune disease processes in many diseases such as diabetes, atherosclerosis, depression, Alzheimer’s disease, systemic lupus erythematosus, multiple myeloma, prostate cancer, leukemia, and rheumatoid arthritis. Patients with advanced/metastatic cancer have high levels of IL-6 in their blood.
IL6 Target Infomation Overview
- Target Symbol: IL6, interleukin 6
- Gene Groups: Interferons; Interleukins; Interleukin 6 type cytokine family
- Alias: IL-6; BSF2; HGF; HSF
- Previous Names: IFNB2
- Alias Names: interferon, beta 2; interleukin 6 (interferon, beta 2)
IL6, interleukin 6 Target Infomation by Species
- Human
- Mouse
- Rat
Human IL6 Target Information
- Target Symbol: IL6, interleukin 6
- Alias:
- B cell stimulatory factor-2
- B-cell differentiation factor
- B-cell stimulatory factor 2
- BSF-2
- BSF2
- CDF
- CTL differentiation factor
- HGF
- HSF
- hybridoma growth factor
- IFN-beta-2
- IFNB2
- IL-6
- interferon beta-2
- interferon, beta 2
- interleukin BSF-2
- interleukin-6
- NCBI_Gene: 3569
- UniProtKB: P05231
Human IL6 Predicted Functions
Enables cytokine activity and growth factor activity. Contributes to interleukin-6 receptor binding activity. Involved in several processes, including positive regulation of cell population proliferation; positive regulation of macromolecule metabolic process; and regulation of peptide hormone secretion. Acts upstream of or within several processes, including cellular response to lipopolysaccharide; positive regulation of leukocyte adhesion to vascular endothelial cell; and positive regulation of macromolecule metabolic process. Located in extracellular space. Part of interleukin-6 receptor complex. Implicated in several diseases, including autoimmune disease (multiple); eye disease (multiple); gastrointestinal system cancer (multiple); glucose metabolism disease (multiple); and periodontal disease (multiple). Biomarker of several diseases, including autoimmune disease (multiple); eye disease (multiple); gastrointestinal system cancer (multiple); glucose metabolism disease (multiple); and lung disease (multiple).
Mouse Il6 Target Information
- Target Symbol: Il6, interleukin 6
- Alias:
- Il-6
- NCBI_Gene: 16193
Mouse Il6 Predicted Functions
Enables cytokine activity and interleukin-6 receptor binding activity. Involved in several processes, including animal organ development; positive regulation of macromolecule metabolic process; and regulation of peptide hormone secretion. Acts upstream of or within with a positive effect on gene expression. Acts upstream of or within several processes, including cellular response to cytokine stimulus; regulation of gene expression; and salivary gland morphogenesis. Located in external side of plasma membrane and extracellular space. Part of interleukin-6 receptor complex. Is expressed in several structures, including adrenal gland; genitourinary system; gut; liver; and thymus. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); gastrointestinal system cancer (multiple); glucose metabolism disease (multiple); and periodontal disease (multiple). Orthologous to human IL6 (interleukin 6).
Rat Il6 Target Information
- Target Symbol: Il6, interleukin 6
- Alias:
- Ifnb2
- IL-6
- ILg6
- Interleukin 6 (interferon beta 2)
- Interleukin 6 (interferon, beta 2)
- interleukin-6
- NCBI_Gene: 24498
- UniProtKB: P20607
Rat Il6 Predicted Functions
Enables cytokine activity and interleukin-6 receptor binding activity. Involved in several processes, including cellular response to lipid; positive regulation of cell communication; and response to peptide hormone. Located in cytoplasm and extracellular space. Used to study several diseases, including acute necrotizing pancreatitis; disseminated intravascular coagulation; fatty liver disease; hypertension (multiple); and impotence. Biomarker of several diseases, including acute necrotizing pancreatitis; artery disease (multiple); auditory system disease (multiple); iron deficiency anemia; and lung disease (multiple). Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); eye disease (multiple); gastrointestinal system cancer (multiple); glucose metabolism disease (multiple); and periodontal disease (multiple). Orthologous to human IL6 (interleukin 6).
