HGNC ID: 10611
Target Abstract:
The chemokine CC ligand 13 (CCL13), also known as monocyte chemotactic protein 4 (MCP-4), is a small molecule cytokine in the CC chemokine family. Its gene is located on human chromosome 17 in a large cluster of other CC chemokines.CCL13 chemotaxis monocytes, eosinophils, T-lymphocytes, and basophils by binding to cell-surface G-protein-linked chemokine receptors, such as CCR2, CCR3, and CCR5.CCL13 activity is involved in allergic reactions such as asthma. Inflammatory cytokines such as IL-1 and TNF-α induce CCL13.
CCL13 Target Infomation Overview
- Target Symbol: CCL13, C-C motif chemokine ligand 13
- Gene Groups: Chemokine ligands
- Alias: MCP-4; NCC-1; SCYL1; CKb10; MGC17134
- Previous Names: SCYA13
- Alias Names: small inducible cytokine subfamily A (Cys-Cys), member 13; chemokine (C-C motif) ligand 13
CCL13, C-C motif chemokine ligand 13 Target Infomation by Species
- Human
- Mouse
- Rat
Human CCL13 Target Information
- Target Symbol: CCL13, C-C motif chemokine ligand 13
- Alias:
- C-C motif chemokine 13
- chemokine (C-C motif) ligand 13
- CK-beta-10
- CKb10
- MCP-4
- MGC17134
- monocyte chemoattractant protein 4
- monocyte chemotactic protein 4
- NCC-1
- NCC1
- new CC chemokine 1
- SCYA13
- SCYL1
- small inducible cytokine subfamily A (Cys-Cys), member 13
- small-inducible cytokine A13
- NCBI_Gene: 6357
- UniProtKB: Q99616
Human CCL13 Predicted Functions
Enables chemokine activity. Involved in several processes, including antimicrobial humoral immune response mediated by antimicrobial peptide; eosinophil chemotaxis; and regulation of cell shape. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Implicated in multiple sclerosis.
Mouse Ccl11 Target Information
- Target Symbol: Ccl11, chemokine (C-C motif) ligand 11
- Alias:
- eotaxin
- Scya11
- small inducible cytokine A11
- NCBI_Gene: 20292
Mouse Ccl11 Predicted Functions
Predicted to enable CCR3 chemokine receptor binding activity; chemokine activity; and protein dimerization activity. Involved in several processes, including modulation of age-related behavioral decline; negative regulation of neurogenesis; and positive regulation of angiogenesis. Acts upstream of or within branching involved in mammary gland duct morphogenesis and mammary duct terminal end bud growth. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in embryo; endocardial lining; liver parenchyma; liver vasculature; and yolk sac blood vessel. Human ortholog(s) of this gene implicated in asthma; human immunodeficiency virus infectious disease; hyperglycemia; and multiple sclerosis. Orthologous to several human genes including CCL11 (C-C motif chemokine ligand 11).
Rat Ccl12 Target Information
- Target Symbol: Ccl12, chemokine (C-C motif) ligand 12
- Alias:
- LOC287562
- MCP-5
- monocyte chemotactic protein 5
- NCBI_Gene: 287562
- UniProtKB: D4ABS1
Rat Ccl12 Predicted Functions
Predicted to enable CCR2 chemokine receptor binding activity and chemokine activity. Involved in negative regulation of leukocyte proliferation and positive regulation of leukocyte migration. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in several diseases, including Henoch-Schoenlein purpura; aggressive periodontitis; autoimmune disease (multiple); gastrointestinal system cancer (multiple); and tuberculosis (multiple). Orthologous to several human genes including CCL8 (C-C motif chemokine ligand 8).
