HGNC ID: 5465
Target Abstract:
The insulin-like growth factor 1 receptor (IGF-1R), located on the surface of human cells, is a transmembrane receptor activated by the hormone insulin-like growth factor 1 (IGF-1) and another related hormone, insulin-like growth factor 2 (IGF-2), and belongs to a large class of tyrosine kinase receptors.IGF-1R mediates the function of IGF-1, a polypeptide molecularly similar in structure to the insulin protein hormone that has an important role in growth and development and adult anabolism and can cause hyperproliferation of skeletal muscle or other target tissues. Mice deficient in IGF-1R die late in development, as evidenced by dramatic weight loss, demonstrating the strong growth-promoting effects of this receptor. Studies have linked IGF-1R to a number of cancers, including breast, prostate and lung cancer.
IGF1R Target Infomation Overview
- Target Symbol: IGF1R, insulin like growth factor 1 receptor
- Gene Groups: Receptor tyrosine kinases; CD molecules; Fibronectin type III domain containing; MicroRNA protein coding host genes
- Alias: JTK13; CD221; IGFIR; MGC18216; IGFR
- Alias Names: insulin-like growth factor 1 receptor
IGF1R, insulin like growth factor 1 receptor Target Infomation by Species
- Human
- Mouse
- Rat
Human IGF1R Target Information
- Target Symbol: IGF1R, insulin like growth factor 1 receptor
- Alias:
- CD221
- IGF-I receptor
- IGFIR
- IGFR
- insulin-like growth factor 1 receptor
- insulin-like growth factor I receptor
- JTK13
- MGC142170
- MGC142172
- MGC18216
- soluble IGF1R variant 1
- soluble IGF1R variant 2
- NCBI_Gene: 3480
- UniProtKB: P08069
Human IGF1R Predicted Functions
Enables several functions, including insulin binding activity; insulin receptor binding activity; and insulin receptor substrate binding activity. Involved in several processes, including cellular response to amyloid-beta; insulin-like growth factor receptor signaling pathway; and regulation of MAPK cascade. Acts upstream of or within peptidyl-tyrosine autophosphorylation. Located in intracellular membrane-bounded organelle and membrane. Part of alphav-beta3 integrin-IGF-1-IGF1R complex; protein kinase complex; and receptor complex. Implicated in several diseases, including IgA glomerulonephritis; dementia (multiple); kidney cancer (multiple); liver disease (multiple); and nervous system cancer (multiple). Biomarker of several diseases, including Kuhnt-Junius degeneration; autoimmune disease (multiple); endocrine gland cancer (multiple); neurodegenerative disease (multiple); and prostate disease (multiple).
Mouse Igf1r Target Information
- Target Symbol: Igf1r, insulin-like growth factor I receptor
- Alias:
- A330103N21Rik
- CD221
- hydrops fetalis
- hyft
- IGF-1R
- line 186
- RIKEN cDNA A330103N21 gene
- NCBI_Gene: 16001
Mouse Igf1r Predicted Functions
Enables insulin-like growth factor binding activity. Involved in several processes, including adrenal gland development; positive regulation of cold-induced thermogenesis; and positive regulation of meiotic cell cycle. Acts upstream of or within several processes, including gland development; peptidyl-tyrosine autophosphorylation; and regulation of intracellular signal transduction. Located in T-tubule. Is integral component of membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; limb; and lung. Human ortholog(s) of this gene implicated in several diseases, including dementia (multiple); kidney cancer (multiple); liver disease (multiple); nervous system cancer (multiple); and neurodegenerative disease (multiple). Orthologous to human IGF1R (insulin like growth factor 1 receptor).
Rat Igf1r Target Information
- Target Symbol: Igf1r, insulin-like growth factor 1 receptor
- Alias:
- IGF-1 receptor
- IGF-I receptor
- IGFIRC
- Igfr1
- insulin-like growth factor I receptor
- JTK13
- type-I IGF receptor
- NCBI_Gene: 25718
Rat Igf1r Predicted Functions
Enables G-protein alpha-subunit binding activity; insulin receptor substrate binding activity; and insulin-like growth factor-activated receptor activity. Involved in several processes, including cellular response to hormone stimulus; negative regulation of apoptotic process; and nervous system development. Located in several cellular components, including T-tubule; caveola; and neuronal cell body. Used to study Alzheimer’s disease; Parkinson’s disease; and prostate adenocarcinoma. Biomarker of several diseases, including alcoholic neuropathy; artery disease (multiple); cryptorchidism; diabetes mellitus (multiple); and neurodegenerative disease (multiple). Human ortholog(s) of this gene implicated in several diseases, including IgA glomerulonephritis; dementia (multiple); kidney cancer (multiple); liver disease (multiple); and nervous system cancer (multiple). Orthologous to human IGF1R (insulin like growth factor 1 receptor).
