HGNC ID: 5469
Target Abstract:
Insulin-like growth factor-binding protein 1 (IGFBP-1), also known as placental protein 12 (PP12), is a protein encoded by the IGFBP1 gene. It binds insulin-like growth factors (IGFs) I and II and circulates in plasma. Such binding prolongs the half-life of IGFs and alters their interaction with cell surface receptors.IGFBPs regulate the biological activity of IGF proteins.Post-transcriptional modifications of IGFBP (e.g., glycosylation, phosphorylation, and protein hydrolysis) alter the affinity of the bound protein for IGFs. High levels of IGFBP-1 may be a marker of catabolic status, and studies have shown that women with high levels of IGFBP-1 have less muscle mass. Higher serum IGFBP-1/IGF-1 ratios in patients with nasopharyngeal carcinoma are significantly associated with poorer prognosis. Local IGFBP1 levels have been reported to have an effect on coronary plaque formation.
IGFBP1 Target Infomation Overview
- Target Symbol: IGFBP1, insulin like growth factor binding protein 1
- Gene Groups: Insulin like growth factor binding proteins
- Alias: IGF-BP25; AFBP; hIGFBP-1; PP12
- Previous Names: IBP1
- Alias Names: placental protein 12; amniotic fluid binding protein; alpha-pregnancy-associated endometrial globulin; growth hormone independent-binding protein; binding protein-28; binding protein-26; binding protein-25; IGF-binding protein 1; insulin-like growth factor binding protein 1
IGFBP1, insulin like growth factor binding protein 1 Target Infomation by Species
- Human
- Mouse
- Rat
Human IGFBP1 Target Information
- Target Symbol: IGFBP1, insulin like growth factor binding protein 1
- Alias:
- AFBP
- alpha-pregnancy-associated endometrial globulin
- amniotic fluid binding protein
- binding protein-25
- binding protein-26
- binding protein-28
- growth hormone independent-binding protein
- hIGFBP-1
- IBP-1
- IBP1
- IGF-binding protein 1
- IGF-BP25
- IGFBP-1
- insulin-like growth factor binding protein 1
- insulin-like growth factor-binding protein 1
- placental protein 12
- PP12
- NCBI_Gene: 3484
- UniProtKB: P08833
Human IGFBP1 Predicted Functions
Enables insulin-like growth factor I binding activity and insulin-like growth factor II binding activity. Predicted to be involved in regulation of insulin-like growth factor receptor signaling pathway. Located in Golgi apparatus. Implicated in diabetic angiopathy. Biomarker of breast cancer.
Mouse Igfbp1 Target Information
- Target Symbol: Igfbp1, insulin-like growth factor binding protein 1
- Alias:
- IGFBP-1
- NCBI_Gene: 16006
Mouse Igfbp1 Predicted Functions
Enables insulin-like growth factor binding activity. Predicted to be involved in regulation of insulin-like growth factor receptor signaling pathway. Located in extracellular space. Is expressed in several structures, including blastocyst; early embryo; liver; and secondary oocyte. Human ortholog(s) of this gene implicated in diabetic angiopathy. Orthologous to human IGFBP1 (insulin like growth factor binding protein 1).
Rat Igfbp1 Target Information
- Target Symbol: Igfbp1, insulin-like growth factor binding protein 1
- Alias:
- IBP-1
- IBP1
- IGF-binding protein 1
- IGF-BP25
- IGFBA
- IGFBP-1
- insulin-like growth factor-binding protein 1
- placental protein 12
- NCBI_Gene: 25685
- UniProtKB: P21743
Rat Igfbp1 Predicted Functions
Predicted to enable insulin-like growth factor I binding activity and insulin-like growth factor II binding activity. Involved in several processes, including insulin receptor signaling pathway; positive regulation of cell growth; and tissue regeneration. Located in extracellular space. Human ortholog(s) of this gene implicated in diabetic angiopathy. Orthologous to human IGFBP1 (insulin like growth factor binding protein 1).
