HGNC ID: 11255
Target Abstract:
Osteobridging protein (OPN), also known as BSP-1, ETA-1, SPP-1, or Ric, is encoded by the SPP1 gene in humans and is expressed predominantly in bone.The regulatory mechanisms of the OPN gene have not been fully elucidated and are different for different cell types.OPN has a role in biomineralization, bone remodeling, immune function, chemotaxis, cell activation, and apoptosis, and has been similarly implicated in cardiomyocyte Apoptosis and increased myocardial dysfunction.OPN is associated with many physiological and pathological processes including wound healing, bone conversion, tumorigenesis, inflammation, ischemia, and immune response. Modulation of plasma (or local) OPN levels has been useful in the treatment of autoimmune diseases, cancer metastasis, bone and tooth mineralization, osteoporosis, and some forms of stress.
SPP1 Target Infomation Overview
- Target Symbol: SPP1, secreted phosphoprotein 1
- Gene Groups: Receptor ligands; SIBLING family
- Alias: BSPI; ETA-1
- Previous Names: BNSP; OPN
- Alias Names: early T-lymphocyte activation 1; osteopontin; bone sialoprotein I
SPP1, secreted phosphoprotein 1 Target Infomation by Species
- Human
- Mouse
- Rat
Human SPP1 Target Information
- Target Symbol: SPP1, secreted phosphoprotein 1
- Alias:
- BNSP
- bone sialoprotein 1
- bone sialoprotein I
- BSPI
- early T-lymphocyte activation 1
- ETA-1
- MGC110940
- nephropontin
- OPN
- osteopontin
- osteopontin-C
- osteopontin-D
- osteopontin/immunoglobulin alpha 1 heavy chain constant region fusion protein
- secreted phosphoprotein 1 (osteopontin, bone sialoprotein I, early T-lymphocyte activation 1)
- secreted phosphoprotein 1 variant 6
- secreted phosphoprotein-1 (osteopontin, bone sialoprotein)
- SPP-1
- SPP1/CALPHA1 fusion
- urinary stone protein
- uropontin
- NCBI_Gene: 6696
- UniProtKB: P10451
Human SPP1 Predicted Functions
Enables integrin binding activity. Involved in several processes, including androgen catabolic process; cellular response to testosterone stimulus; and positive regulation of estradiol secretion. Located in Golgi apparatus and extracellular space. Implicated in several diseases, including autoimmune disease (multiple); biliary atresia; coronary artery disease (multiple); disease of cellular proliferation (multiple); and hepatitis. Biomarker of calcinosis; coronary artery disease; kidney failure; progressive osseous heteroplasia; and urinary bladder cancer.
Mouse Spp1 Target Information
- Target Symbol: Spp1, secreted phosphoprotein 1
- Alias:
- 2ar
- 44kDa bone phosphoprotein
- AA960535
- activation protein lymphocyte 1
- AI790405
- Apl-1
- BNSP
- bone sialoprotein 1
- early T lymphocyte activation
- Eta
- ETA-1
- expressed sequence AA960535
- expressed sequence AI790405
- minopontin
- OP
- Opn
- Opnl
- osteopontin
- osteopontin-like protein
- Ric
- rickettsia tsutsugamushi resistance
- Spp-1
- NCBI_Gene: 20750
Mouse Spp1 Predicted Functions
Enables extracellular matrix binding activity. Acts upstream of or within several processes, including cellular ion homeostasis; cellular response to leukemia inhibitory factor; and neutrophil chemotaxis. Located in apical part of cell and cytoplasm. Is expressed in several structures, including alimentary system; brain; metanephros; reproductive system; and skeleton. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); biliary atresia; coronary artery disease (multiple); disease of cellular proliferation (multiple); and hepatitis. Orthologous to human SPP1 (secreted phosphoprotein 1).
Rat Spp1 Target Information
- Target Symbol: Spp1, secreted phosphoprotein 1
- Alias:
- bone sialoprotein 1
- LOC100359743
- OSP
- osteopontin
- osteopontin-like
- Sialoprotein (osteopontin)
- SPP-1
- NCBI_Gene: 25353
- UniProtKB: P08721
Rat Spp1 Predicted Functions
Predicted to enable extracellular matrix binding activity and integrin binding activity. Involved in several processes, including negative regulation of collateral sprouting of intact axon in response to injury; osteoblast differentiation; and positive regulation of bone resorption. Located in several cellular components, including extracellular space; perinuclear region of cytoplasm; and vesicle. Used to study several diseases, including encephalomyelitis; myocarditis; radiculopathy; renovascular hypertension; and visual epilepsy. Biomarker of autosomal dominant polycystic kidney disease; calcinosis; and glomerulosclerosis. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); biliary atresia; coronary artery disease (multiple); disease of cellular proliferation (multiple); and hepatitis. Orthologous to human SPP1 (secreted phosphoprotein 1).
