HGNC ID: 13765
Target Abstract:
Interleukin 17E (IL-17E), also known as IL-25, is a member of the IL-17 family and is secreted and produced by type 2 helper T cells (Th2) and mast cells. It is similar in sequence to IL-17 and induces NF-κB activation and stimulates IL-8 production.IL-17E and IL-17B are ligands for the cytokine receptor IL-17RB. Studies in mice suggest that IL-17E may be a pro-inflammatory cytokine that facilitates the Th2-type immune response.IL-17E induces the production of other cytokines in a variety of tissues, including IL-4, IL-5, and IL-13, which stimulates eosinophilia. This cytokine is an important molecule in the regulation of intestinal immunity and is involved in chronic inflammation associated with the gastrointestinal tract.IL-17E kills certain types of breast cancer cells.
IL25 Target Infomation Overview
- Target Symbol: IL25, interleukin 25
- Gene Groups: Interleukins
- Alias: IL-25; IL-17E
- Previous Names: IL17E
- Alias Names: interleukin 17E
IL25, interleukin 25 Target Infomation by Species
- Human
- Mouse
- Rat
Human IL25 Target Information
- Target Symbol: IL25, interleukin 25
- Alias:
- IL-17E
- IL-25
- IL17E
- interleukin 17E
- interleukin-17E
- interleukin-25
- NCBI_Gene: 64806
- UniProtKB: Q9H293
Human IL25 Predicted Functions
Predicted to enable interleukin-17E receptor binding activity. Predicted to be involved in inflammatory response to antigenic stimulus and signal transduction. Predicted to act upstream of or within several processes, including eosinophil differentiation; response to fungus; and response to nematode. Predicted to be located in extracellular region. Biomarker of atopic dermatitis and psoriasis.
Mouse Il25 Target Information
- Target Symbol: Il25, interleukin 25
- Alias:
- IL-17E
- Il17e
- interleukin 17E
- NCBI_Gene: 140806
Mouse Il25 Predicted Functions
Enables cytokine activity. Acts upstream of or within several processes, including eosinophil differentiation; response to fungus; and response to nematode. Predicted to be located in extracellular space. Orthologous to human IL25 (interleukin 25).
Rat Il25 Target Information
- Target Symbol: Il25, interleukin 25
- Alias:
- interleukin-25
- LOC501996
- RGD1561632
- similar to IL25
- NCBI_Gene: 501996
- UniProtKB: D3ZLB1
Rat Il25 Predicted Functions
Predicted to enable cytokine activity. Involved in inflammatory response to antigenic stimulus. Located in extracellular space. Biomarker of gastric ulcer. Orthologous to human IL25 (interleukin 25).
