Target Abstract: CD5L, also known as CD5 antigen-like, is a soluble protein belonging to group B of the scavenger receptor cysteine-rich (SRCR) superfamily and contains three SRCR domains. It is a secreted glycoprotein and expressed by macrophages presentin lymphoid tissues (spleen, lymph node, thymus, and bone marrow). It binds to myelomonocytic and lymphoid cells and may play an important role in the regulation of the innate and adaptive immune systems. CD5L functions as a pattern recognition molecule by binding both lipoteichoic acid (LTA) on Gram positive and lipopolysaccharide (LPS) on Gram negative bacteria. and the SRCR domain 1 of CD5L retains both the LPS and LTA binding activities. In addtion, it is revealed that CD5L seems to play a role as an inhibitor of apoptosis.
CD5L Target Infomation Overview
- Target Symbol: CD5L, CD5 molecule like
- Gene Groups: Scavenger receptor cysteine rich domain containing
- Alias: Spalpha, API6
- Alias Names: apoptosis inhibitor 6; CD5 antigen-like (scavenger receptor cysteine rich family); CD5 molecule-like
CD5L, CD5 molecule like Target Infomation by Species
- Human
- Mouse
- Rat
Human CD5L Target Information
- Target Symbol: CD5L, CD5 molecule like
- Alias:
- AIM
- API6
- apoptosis inhibitor 6
- apoptosis inhibitor expressed by macrophages
- apoptosis inhibitor of macrophage
- CD5 antigen-like
- CD5 antigen-like (scavenger receptor cysteine rich family)
- CD5 molecule-like
- CT-2
- hAIM
- igM-associated peptide
- PRO229
- SP-ALPHA
- Spalpha
- NCBI_Gene: 922
- UniProtKB: P43866
Human CD5L Predicted Functions
Predicted to be involved in cellular defense response. Predicted to act upstream of or within positive regulation of complement-dependent cytotoxicity and regulation of complement activation. Located in cell surface.
Mouse Cd5l Target Information
- Target Symbol: Cd5l, CD5 antigen-like
- Alias:
- AAC-11
- AI047839
- AIM
- AIM/Spalpha
- Api6
- apoptosis inhibitor 6
- expressed sequence AI047839
- Pdp 1/6
- Sp-alpha
- NCBI_Gene: 11801
Mouse Cd5l Predicted Functions
Acts upstream of or within positive regulation of complement-dependent cytotoxicity and regulation of complement activation. Located in cell surface and plasma membrane. Is expressed in several structures, including central nervous system; immune system; liver; retina; and testis. Orthologous to human CD5L (CD5 molecule like).
Rat Cd5l Target Information
- Target Symbol: Cd5l, CD5 antigen-like
- Alias:
- CD5 antigen-like
- LOC310693
- MGC112716
- NCBI_Gene: 310693
Rat Cd5l Predicted Functions
Predicted to act upstream of or within positive regulation of complement-dependent cytotoxicity and regulation of complement activation. Predicted to be located in cell surface. Predicted to be active in plasma membrane. Orthologous to human CD5L (CD5 molecule like).
