HGNC ID: 7656
Target Abstract:
CD56, also known as Neural Cell Adhesion molecule (NCAM), Leu-19, or NKH1, is a transmembrane glycoprotein with a molecular weight of 140 kD. CD56 is expressed in neurons and plays a role in the homogenous adhesion of nerve cells. In the hematopoietic system, it is expressed in NK and NKT cells and plays a role in cell adhesion.
NCAM1 Target Infomation Overview
- Target Symbol: NCAM1, neural cell adhesion molecule 1
- Gene Groups: CD molecules; Fibronectin type III domain containing; I-set domain containing; Ig-like cell adhesion molecule family
- Alias: NCAM; CD56
NCAM1, neural cell adhesion molecule 1 Target Infomation by Species
- Human
- Mouse
- Rat
Human NCAM1 Target Information
- Target Symbol: NCAM1, neural cell adhesion molecule 1
- Alias:
- antigen recognized by monoclonal antibody 5.1H11
- CD56
- MSK39
- N-CAM-1
- NCAM
- NCAM-1
- neural cell adhesion molecule, NCAM
- NCBI_Gene: 4684
- UniProtKB: P13591
Human NCAM1 Predicted Functions
Predicted to enable virus receptor activity. Predicted to be involved in commissural neuron axon guidance; modulation of chemical synaptic transmission; and regulation of semaphorin-plexin signaling pathway. Predicted to act upstream of or within several processes, including homotypic cell-cell adhesion; positive regulation of calcium-mediated signaling; and regulation of exocyst assembly. Located in cytosol and external side of plasma membrane. Implicated in bipolar disorder; middle cerebral artery infarction; and pancreatic cancer. Biomarker of several diseases, including acute promyelocytic leukemia; brain glioblastoma multiforme; cholangiocarcinoma; insulinoma; and ovarian serous carcinoma.
Mouse Ncam1 Target Information
- Target Symbol: Ncam1, neural cell adhesion molecule 1
- Alias:
- CD56
- E-NCAM
- NCAM
- NCAM-1
- NCAM-120
- NCAM-140
- NCAM-180
- NCBI_Gene: 17967
Mouse Ncam1 Predicted Functions
Predicted to enable LRR domain binding activity and phosphatase binding activity. Involved in commissural neuron axon guidance and regulation of semaphorin-plexin signaling pathway. Acts upstream of or within several processes, including homotypic cell-cell adhesion; positive regulation of calcium-mediated signaling; and regulation of exocyst assembly. Located in several cellular components, including external side of plasma membrane; growth cone; and neuronal cell body. Is expressed in several structures, including embryo mesenchyme; nervous system; sensory organ; skin; and urinary system. Human ortholog(s) of this gene implicated in bipolar disorder; middle cerebral artery infarction; and pancreatic cancer. Orthologous to human NCAM1 (neural cell adhesion molecule 1).
Rat Ncam1 Target Information
- Target Symbol: Ncam1, neural cell adhesion molecule 1
- Alias:
- Cd56
- Cell adhesion molecule neural (CD56)
- cell adhesion molecule, neural (CD56)
- MGC124601
- N-CAM
- N-CAM-1
- Ncam
- NCAM-1
- NCAM-C
- NCAMC
- neural cell adhesion molecule
- NCBI_Gene: 24586
Rat Ncam1 Predicted Functions
Enables enzyme binding activity. Involved in cellular response to hypoxia; flagellated sperm motility; and spermatogenesis. Located in cytoplasm. Orthologous to several human genes including MST1 (macrophage stimulating 1).