HGNC ID: 1700
Target Abstract:
CD80, also known as B7-1, is a protein found on dendritic cells, activated B cells, and monocytes. It provides necessary co-stimulatory signals for T cell activation and survival. The cDNA of CD80 is predicted to encode a type I transmembrane protein, which is synthesized on the endoplasmic reticulum with a signal peptide. The predicted protein contains two extracellular domains with structural similarity to immunoglobulins (Ig), a hydrophobic transmembrane region, and a short cytoplasmic domain. The CD80 gene, along with the CD86 gene, encodes B7-1 and B7-2, respectively, which are structurally related members of the immunoglobulin superfamily expressed on various hematopoietic cell types. B7-1 and B7-2 provide co-stimulatory signals to T cells by interacting with CD28 and CTLA4.
CD80 Target Infomation Overview
- Target Symbol: CD80, CD80 molecule
- Gene Groups: CD molecules; V-set domain containing; C2-set domain containing; B7 family
- Alias: B7.1; B7-1
- Previous Names: CD28LG; CD28LG1
- Alias Names: B-lymphocyte activation antigen B7; CD80 antigen (CD28 antigen ligand 1, B7-1 antigen); CD80 molecule
CD80, CD80 molecule Target Infomation by Species
- Human
- Mouse
- Rat
Human CD80 Target Information
- Target Symbol: CD80, CD80 molecule
- Alias:
- activation B7-1 antigen
- B-lymphocyte activation antigen B7
- B7
- B7-1
- B7.1
- BB1
- CD28LG
- CD28LG1
- cd80 antigen
- CD80 antigen (CD28 antigen ligand 1, B7-1 antigen)
- costimulatory factor CD80
- costimulatory molecule variant IgV-CD80
- CTLA-4 counter-receptor B7.1
- LAB7
- T-lymphocyte activation antigen CD80
- NCBI_Gene: 941
- UniProtKB: P33681
Human CD80 Predicted Functions
Predicted to enable virus receptor activity. Involved in positive regulation of peptidyl-tyrosine phosphorylation. Located in cell surface. Part of protein complex involved in cell adhesion. Implicated in type 1 diabetes mellitus. Biomarker of chronic obstructive pulmonary disease; demyelinating disease; relapsing-remitting multiple sclerosis; rheumatoid arthritis; and systemic lupus erythematosus.
Mouse Cd80 Target Information
- Target Symbol: Cd80, CD80 antigen
- Alias:
- B7-1
- B7.1
- CD28 antigen ligand
- Cd28l
- Ly-53
- Ly53
- lymphocyte antigen 53
- NCBI_Gene: 12519
Mouse Cd80 Predicted Functions
Predicted to enable coreceptor activity. Acts upstream of or within T cell costimulation; cellular response to lipopolysaccharide; and positive regulation of alpha-beta T cell proliferation. Located in external side of plasma membrane. Is expressed in heart ventricle and skin. Human ortholog(s) of this gene implicated in type 1 diabetes mellitus. Orthologous to human CD80 (CD80 molecule).
Rat Cd80 Target Information
- Target Symbol: Cd80, Cd80 molecule
- Alias:
- B7-1
- Cd80 a rat homolog of the human CD28/CTLA – 4 ligand (B7-1)
- CD80 antigen
- CD80-like
- LOC100360171
- T-lymphocyte activation antigen CD80
- NCBI_Gene: 25408
Rat Cd80 Predicted Functions
Predicted to enable coreceptor activity. Involved in positive regulation of T cell proliferation. Located in cell surface. Used to study adult T-cell leukemia; anti-basement membrane glomerulonephritis; high grade glioma; and periodontal disease. Biomarker of kidney failure. Human ortholog(s) of this gene implicated in type 1 diabetes mellitus. Orthologous to human CD80 (CD80 molecule).
