HGNC ID: 600
Target Abstract:
Apolipoprotein A1 (Apo A1) is the major protein component of high-density lipoprotein (HDL) in plasma. It is also present in chylomicrons secreted by intestinal epithelial cells, but quickly transfers to HDL in the bloodstream. This protein plays specific roles in lipid metabolism, promoting the efflux of fats, including the transport of cholesterol from tissues to the liver for excretion. It acts as a cofactor for lecithin-cholesterol acyltransferase, responsible for the formation of most plasma cholesterol esters. Apo A1 is also a stabilizing factor for prostacyclin, suggesting a potential anticoagulant function. It is commonly used as a biomarker for predicting cardiovascular diseases. The Apo B-100/Apo A1 ratio has been reported as an effective predictor of myocardial infarction risk compared to other lipid measurements. Deletions in the gene encoding Apo A1 are associated with HDL deficiencies, including Tangier disease, and systemic non-neuropathic amyloidosis.
APOA1 Target Infomation Overview
- Target Symbol: APOA1, apolipoprotein A1
- Gene Groups: Apolipoproteins
- Alias Names: apolipoprotein A-I
APOA1, apolipoprotein A1 Target Infomation by Species
- Human
- Mouse
- Rat
Human APOA1 Target Information
- Target Symbol: APOA1, apolipoprotein A1
- Alias:
- apo-AI
- apo(a)
- apoA-I
- apolipoprotein A-I
- HPALP2
- MGC117399
- NCBI_Gene: 335
- UniProtKB: P02647
Human APOA1 Predicted Functions
Enables several functions, including amyloid-beta binding activity; cholesterol binding activity; and signaling receptor binding activity. Contributes to cholesterol transfer activity. Involved in several processes, including lipid homeostasis; lipid transport; and regulation of Rho protein signal transduction. Acts upstream of or within cholesterol transport. Located in endocytic vesicle and extracellular space. Part of spherical high-density lipoprotein particle and very-low-density lipoprotein particle. Implicated in several diseases, including artery disease (multiple); familial visceral amyloidosis; hypolipoproteinemia (multiple); non-alcoholic steatohepatitis; and systemic lupus erythematosus. Biomarker of several diseases, including artery disease (multiple); diabetes mellitus (multiple); end stage renal disease; liver disease (multiple); and neurodegenerative disease (multiple).
Mouse Apoa1 Target Information
- Target Symbol: Apoa1, apolipoprotein A-I
- Alias:
- Alp-1
- Apoa-1
- brain protein 14
- Brp-14
- liver 20-30 thousand M.Wt protein 1
- Ltw-1
- Lvtw-1
- Sep-1
- Sep-2
- Sep2
- serum protein 1
- serum protein 2
- NCBI_Gene: 11806
Mouse Apoa1 Predicted Functions
Enables several functions, including cholesterol transfer activity; high-density lipoprotein particle binding activity; and identical protein binding activity. Acts upstream of or within several processes, including cholesterol biosynthetic process; cholesterol efflux; and regulation of intestinal cholesterol absorption. Located in extracellular space. Is expressed in several structures, including adrenal gland; gonad; gut; liver; and lung. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); familial visceral amyloidosis; hypolipoproteinemia (multiple); non-alcoholic steatohepatitis; and systemic lupus erythematosus. Orthologous to human APOA1 (apolipoprotein A1).
Rat Apoa1 Target Information
- Target Symbol: Apoa1, apolipoprotein A1
- Alias:
- apo-AI
- apoA-I
- apolipoprotein A-1
- apolipoprotein A-I
- preproapolipoprotein A-I
- NCBI_Gene: 25081
- UniProtKB: P04639
Rat Apoa1 Predicted Functions
Enables amyloid-beta binding activity; cholesterol transfer activity; and lipase inhibitor activity. Involved in several processes, including lipid transport; peripheral nervous system axon regeneration; and response to estrogen. Located in cell surface; extracellular space; and nucleus. Part of discoidal high-density lipoprotein particle; intermediate-density lipoprotein particle; and low-density lipoprotein particle. Used to study arteriosclerosis and hyperthyroidism. Biomarker of several diseases, including fatty liver disease (multiple); hypertension; major depressive disorder; ocular hypertension; and sciatic neuropathy. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); familial visceral amyloidosis; hypolipoproteinemia (multiple); non-alcoholic steatohepatitis; and systemic lupus erythematosus. Orthologous to human APOA1 (apolipoprotein A1).
