HGNC ID: 3612
Target Abstract:
CD23 is a 45kDa type II transmembrane glycoprotein. CD23 is a type II membrane protein that can be expressed by B cells, monocytes, macrophages, eosinophils, platelets, and dendritic cells. CD23 can mediate IgE dependent cytotoxicity and phagocytosis of macrophages and eosinophils.
FCER2 Target Infomation Overview
- Target Symbol: FCER2, Fc epsilon receptor II
- Gene Groups: CD molecules; C-type lectin domain containing
- Alias: CLEC4J; CD23; FCErII; FcepsilonRII
- Previous Names: CD23A; FCE2
- Alias Names: Fc epsilon RII; C-type lectin domain family 4 member J; Fc fragment of IgE, low affinity II, receptor for (CD23A); Fc fragment of IgE, low affinity II, receptor for (CD23); Fc fragment of IgE receptor II
FCER2, Fc epsilon receptor II Target Infomation by Species
- Human
- Mouse
- Rat
Human FCER2 Target Information
- Target Symbol: FCER2, Fc epsilon receptor II
- Alias:
- BLAST-2
- C-type lectin domain family 4 member J
- C-type lectin domain family 4, member J
- CD23
- CD23 antigen
- CD23A
- CLEC4J
- Fc epsilon receptor II
- Fc fragment of IgE, low affinity II, receptor for (CD23)
- fc fragment of ige, low affinity ii, receptor for (cd23a)
- fc-epsilon-RII
- FCE2
- IGEBF
- immunoglobulin E-binding factor
- immunoglobulin epsilon-chain
- low affinity immunoglobulin epsilon Fc receptor
- lymphocyte IgE receptor
- NCBI_Gene: 2208
- UniProtKB: P06734
Human FCER2 Predicted Functions
Predicted to enable integrin binding activity. Involved in positive regulation of killing of cells of other organism; positive regulation of nitric-oxide synthase activity; and positive regulation of nitric-oxide synthase biosynthetic process. Located in extracellular exosome.
Mouse Fcer2a Target Information
- Target Symbol: Fcer2a, Fc receptor, IgE, low affinity II, alpha polypeptide
- Alias:
- CD23
- Fc epsilon low affinity receptor (IgE)
- FC epsilon RII
- Fce2
- low-affinity IgE receptor
- Ly-42
- lymphocyte antigen 42
- NCBI_Gene: 14128
Mouse Fcer2a Predicted Functions
Predicted to enable carbohydrate binding activity. Acts upstream of or within positive regulation of humoral immune response mediated by circulating immunoglobulin. Located in external side of plasma membrane. Orthologous to human FCER2 (Fc fragment of IgE receptor II).
Rat Fcer2 Target Information
- Target Symbol: Fcer2, Fc epsilon receptor II
- Alias:
- CD23
- Fc fragment of IgE, low affinity II, receptor for (CD23)
- Fc receptor alpha multiple ligand receptor
- Fc receptor alpha, multiple ligand receptor
- Fc receptor, IgE, low affinity II, alpha polypeptide
- Fcalpha muR
- Fcalpha RII
- Fcer2a
- low affinity immunoglobulin epsilon Fc receptor
- MGC93219
- NCBI_Gene: 171075
Rat Fcer2 Predicted Functions
Predicted to enable carbohydrate binding activity. Predicted to be involved in positive regulation of killing of cells of other organism; positive regulation of nitric-oxide synthase activity; and positive regulation of nitric-oxide synthase biosynthetic process. Predicted to act upstream of or within positive regulation of humoral immune response mediated by circulating immunoglobulin. Predicted to be integral component of membrane. Predicted to be active in external side of plasma membrane. Orthologous to human FCER2 (Fc fragment of IgE receptor II).