Target Abstract: Heat shock proteins (HSPs) are classified into five categories based on their molecular size: HSP110, HSP90, HSP70, HSP60, and small Heat Shock Proteins (sHSPs). HSP90 is one of the most abundant proteins in the human body, with 1-2 out of every 100 proteins in the cell being composed of HSP90. It is also one of the essential molecular chaperones in cells, expressed in all eukaryotic cells, and its expression is 2 to 10 times higher in tumor cells compared to normal cells. HSP90 is mainly divided into four isoforms: HSP90α, HSP90β, Grp94, and Trap-1. HSP90β1 consists of 315 amino acids. This gene encodes a member of the adenosine triphosphate (ATP) metabolism chaperone family, which plays a role in stabilizing and folding other proteins. The encoded protein is localized to melanosomes and theendoplasmic reticulum. Expression of this protein is associated withriouspathological conditions, including tumor formation. A microRNA gene is located within the 5' exon of this gene.Pseudogenes of this gene exist on chromosomes 1 and 15.
HSP90B1 Target Infomation Overview
- Target Symbol: HSP90B1, heat shock protein 90 beta family member 1
- Gene Groups: Heat shock 90kDa proteins; MicroRNA protein coding host genes
- Alias: GP96; GRP94, TRA1
- Alias Names: tumor rejection antigen (gp96) 1; heat shock protein 90kDa beta (Grp94), member 1; endoplasmin
HSP90B1, heat shock protein 90 beta family member 1 Target Infomation by Species
- Human
- Mouse
- Rat
Human HSP90B1 Target Information
- Target Symbol: HSP90B1, heat shock protein 90 beta family member 1
- Alias:
- 94 kDa glucose-regulated protein
- ECGP
- endoplasmin
- endothelial cell (HBMEC) glycoprotein
- epididymis luminal protein 35
- epididymis secretory sperm binding protein Li 125m
- glucose regulated protein, 94 kDa
- GP96
- gp96 homolog
- GRP-94
- GRP94
- heat shock protein 90 kDa beta member 1
- heat shock protein 90kDa beta (Grp94), member 1
- heat shock protein 90kDa beta family member 1
- HEL-S-125m
- HEL35
- stress-inducible tumor rejection antigen gp96
- TRA1
- tumor rejection antigen (gp96) 1
- tumor rejection antigen 1
- Tumor rejection antigen-1 (gp96)
- NCBI_Gene: 7184
- UniProtKB: P14625
Human HSP90B1 Predicted Functions
Enables RNA binding activity; low-density lipoprotein particle receptor binding activity; and protein phosphatase binding activity. Involved in negative regulation of apoptotic process; response to hypoxia; and retrograde protein transport, ER to cytosol. Acts upstream of or within actin rod assembly and cellular response to ATP. Located in several cellular components, including endoplasmic reticulum; midbody; and perinuclear region of cytoplasm. Part of protein-containing complex. Biomarker of lung adenocarcinoma.
Mouse Hsp90b1 Target Information
- Target Symbol: Hsp90b1, heat shock protein 90, beta (Grp94), member 1
- Alias:
- 90 kDa
- endoplasmin
- ERp99
- gp96
- GRP94
- Grp94
- Targ2
- Tra-1
- Tra1
- transforming growth factor alpha regulated gene 2
- tumor rejection antigen (gp96) 1
- tumor rejection antigen gp96
- NCBI_Gene: 22027
Mouse Hsp90b1 Predicted Functions
Predicted to enable several functions, including low-density lipoprotein particle receptor binding activity; protein folding chaperone; and unfolded protein binding activity. Predicted to be involved in ERAD pathway; insulin processing; and protein folding. Predicted to act upstream of or within actin rod assembly and cellular response to ATP. Located in endoplasmic reticulum and sperm plasma membrane. Part of endoplasmic reticulum chaperone complex. Is expressed in several structures, including central nervous system; heart; metanephros; pancreas; and respiratory system. Used to study male infertility due to globozoospermia. Orthologous to several human genes including HSP90B1 (heat shock protein 90 beta family member 1).
Rat Hsp90b1 Target Information
- Target Symbol: Hsp90b1, heat shock protein 90 beta family member 1
- Alias:
- 94 kDa glucose-regulated protein
- endoplasmin
- GRP-94
- GRP94
- heat shock protein 90 kDa beta member 1
- heat shock protein 90, beta, member 1
- heat shock protein 90kDa beta (Grp94), member 1
- LOC362862
- Tra1
- tumor rejection antigen gp96
- NCBI_Gene: 362862
Rat Hsp90b1 Predicted Functions
Predicted to enable several functions, including low-density lipoprotein particle receptor binding activity; protein phosphatase binding activity; and unfolded protein binding activity. Involved in cellular response to manganese ion. Located in smooth endoplasmic reticulum. Orthologous to several human genes including HSP90B1 (heat shock protein 90 beta family member 1).
