HGNC ID: 6553
Target Abstract:
Leptin is a protein-like hormone secreted by adipocytes that regulates energy balance by suppressing hunger. In addition to white adipose tissue, which secretes leptin, brown fat, placenta, ovaries, skeletal muscle, stomach, breast epithelial cells, bone marrow, and P/D1 cells also produce leptin. Both leptin and the hunger hormone act on receptors in the arcuate nucleus of the hypothalamus as a means of regulating appetite and obtaining energy balance. The basic function of leptin is to regulate fat storage, but it also plays a role in other physiological and metabolic processes, yet many other functions remain undefined. Studies have linked leptin to obesity and weight loss.
LEP Target Infomation Overview
- Target Symbol: LEP, leptin
- Gene Groups: Neuropeptides
- Previous Names: OBS; OB
- Alias Names: leptin (murine obesity homolog); leptin (obesity homolog, mouse)
LEP, leptin Target Infomation by Species
- Human
- Mouse
- Rat
Human LEP Target Information
- Target Symbol: LEP, leptin
- Alias:
- FLJ94114
- LEPD
- leptin (murine obesity homolog)
- leptin (obesity homolog, mouse)
- OB
- obese protein
- obese, mouse, homolog of
- obesity factor
- OBS
- NCBI_Gene: 3952
- UniProtKB: P41159
Human LEP Predicted Functions
Enables leptin receptor binding activity. Involved in several processes, including positive regulation of signal transduction; regulation of cytokine production; and regulation of lymphocyte proliferation. Predicted to be located in cytosol. Predicted to be active in extracellular space. Implicated in several diseases, including alcohol dependence; congenital leptin deficiency; liver disease (multiple); lung disease (multiple); and type 2 diabetes mellitus. Biomarker of several diseases, including alcohol dependence; cystic fibrosis; fatty liver disease (multiple); liver disease (multiple); and lung disease (multiple).
Mouse Lep Target Information
- Target Symbol: Lep, leptin
- Alias:
- ob
- obese
- NCBI_Gene: 16846
Mouse Lep Predicted Functions
Enables DNA binding activity and growth factor activity. Involved in several processes, including cell surface receptor signaling pathway; positive regulation of cytokine production; and positive regulation of signal transduction. Acts upstream of or within several processes, including insulin secretion; monocarboxylic acid metabolic process; and regulation of insulin secretion. Located in cytoplasm and extracellular space. Is expressed in several structures, including adipose tissue; alimentary system; central nervous system; early conceptus; and genitourinary system. Used to study abdominal obesity-metabolic syndrome (multiple); fatty liver disease (multiple); obesity; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; congenital leptin deficiency; liver disease (multiple); lung disease (multiple); and type 2 diabetes mellitus. Orthologous to human LEP (leptin).
Rat Lep Target Information
- Target Symbol: Lep, leptin
- Alias:
- OB
- obese
- obesity (murine homolog leptin)
- obesity factor
- NCBI_Gene: 25608
Rat Lep Predicted Functions
Enables hormone activity and peptide hormone receptor binding activity. Involved in several processes, including positive regulation of cell communication; regulation of apoptotic process; and response to vitamin. Located in cytosol and extracellular space. Used to study several diseases, including alcohol dependence; glucose metabolism disease (multiple); liver disease (multiple); neurodegenerative disease (multiple); and short bowel syndrome. Biomarker of several diseases, including Huntington’s disease; alcohol dependence; fatty liver disease (multiple); lipid metabolism disorder (multiple); and obesity. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; congenital leptin deficiency; fatty liver disease (multiple); liver disease (multiple); and lung disease (multiple). Orthologous to human LEP (leptin).
