HGNC ID: 8032
Target Abstract:
Tropomyosin kinase receptor B (TrkB), also known as tyrosine kinase receptor B, is a receptor for brain-derived neurotrophic factor (BDNF) and a member of the neurotrophic factor tyrosine kinase receptor (NTRK) family. This kinase is a membrane-bound receptor that is only expressed in neurons of the central nervous system. TrkB mediates many of the functions of neurotrophic factors such as BDNF, neurotrophic factor-4 (NT-4), and neurotrophic factor-3 (NT-3), including neuronal differentiation and survival. In the extracellular domain, it has two distinct regions that bind BDNF with high affinity. Upon binding to neurotrophic factors, TrkB itself and downstream molecular members of related signaling pathways are phosphorylated. TrkB plays an important role in tumorigenesis and metastasis, and mutations in this gene have been linked to obesity and mood disorders. Therefore, BDNF/TrkB signaling is considered as a potential target for the treatment of schizophrenia.
NTRK2 Target Infomation Overview
- Target Symbol: NTRK2, neurotrophic receptor tyrosine kinase 2
- Gene Groups: Receptor tyrosine kinases; I-set domain containing
- Alias: TRKB
- Alias Names: BDNF/NT-3 growth factors receptor; neurotrophic tyrosine kinase, receptor, type 2
NTRK2, neurotrophic receptor tyrosine kinase 2 Target Infomation by Species
- Human
- Mouse
- Rat
Human NTRK2 Target Information
- Target Symbol: NTRK2, neurotrophic receptor tyrosine kinase 2
- Alias:
- BDNF-tropomyosine receptor kinase B
- BDNF/NT-3 growth factors receptor
- DEE58
- EIEE58
- GP145-TrkB
- neurotrophic tyrosine kinase receptor type 2
- neurotrophic tyrosine kinase, receptor, type 2
- neurotrophic tyrosine receptor kinase type 2
- OBHD
- trk-B
- TRKB
- trkB tyrosine kinase
- tropomyosin-related kinase B
- tyrosine kinase receptor B
- NCBI_Gene: 4915
- UniProtKB: Q16620
Human NTRK2 Predicted Functions
Enables brain-derived neurotrophic factor-activated receptor activity; neurotrophin binding activity; and protease binding activity. Involved in brain-derived neurotrophic factor receptor signaling pathway. Acts upstream of or within negative regulation of amyloid-beta formation. Is integral component of plasma membrane. Part of receptor complex. Implicated in Alzheimer’s disease; autistic disorder; developmental and epileptic encephalopathy 58; major depressive disorder; and morbid obesity. Biomarker of bipolar disorder; idiopathic pulmonary fibrosis; major depressive disorder; and schizophrenia.
Mouse Ntrk2 Target Information
- Target Symbol: Ntrk2, neurotrophic tyrosine kinase, receptor, type 2
- Alias:
- AI848316
- C030027L06Rik
- expressed sequence AI848316
- RIKEN cDNA C030027L06 gene
- Tkrb
- trkB
- tyrosine protein kinase receptor
- NCBI_Gene: 18212
Mouse Ntrk2 Predicted Functions
Enables brain-derived neurotrophic factor binding activity and brain-derived neurotrophic factor-activated receptor activity. Involved in several processes, including brain-derived neurotrophic factor receptor signaling pathway; nervous system development; and trans-synaptic signaling, modulating synaptic transmission. Acts upstream of or within several processes, including neurogenesis; neuronal action potential propagation; and positive regulation of peptidyl-serine phosphorylation. Located in several cellular components, including early endosome; postsynaptic density; and postsynaptic membrane. Is expressed in several structures, including alimentary system; cardiovascular system; future brain; genitourinary system; and nervous system. Human ortholog(s) of this gene implicated in Alzheimer’s disease; autistic disorder; developmental and epileptic encephalopathy 58; major depressive disorder; and morbid obesity. Orthologous to human NTRK2 (neurotrophic receptor tyrosine kinase 2).
Rat Ntrk2 Target Information
- Target Symbol: Ntrk2, neurotrophic receptor tyrosine kinase 2
- Alias:
- BDNF/NT-3 growth factors receptor
- GP145-TrkB/GP95-TrkB
- Neural receptor protein-tyrosine kinase (trkB)
- neurotrophic tyrosine kinase, receptor, type 2
- neurotrophic tyrosine receptor kinase type 2
- RATTRKB1
- Tkrb
- trk-B
- trkB
- trkB tyrosine kinase
- TRKB1
- NCBI_Gene: 25054
Rat Ntrk2 Predicted Functions
Enables several functions, including brain-derived neurotrophic factor binding activity; brain-derived neurotrophic factor-activated receptor activity; and protein homodimerization activity. Involved in several processes, including brain-derived neurotrophic factor receptor signaling pathway; positive regulation of cell communication; and regulation of neuron projection development. Acts upstream of or within positive regulation of glucocorticoid receptor signaling pathway. Located in several cellular components, including distal axon; perikaryon; and postsynaptic density. Is integral component of plasma membrane. Is active in glutamatergic synapse and postsynapse. Used to study glaucoma. Biomarker of several diseases, including attention deficit hyperactivity disorder; colitis; mental depression; post-traumatic stress disorder; and temporal lobe epilepsy. Human ortholog(s) of this gene implicated in Alzheimer’s disease; autistic disorder; developmental and epileptic encephalopathy 58; major depressive disorder; and morbid obesity. Orthologous to human NTRK2 (neurotrophic receptor tyrosine kinase 2).
