HGNC ID: 14687
Target Abstract:
Lymphatic endothelial hyaluronan receptor-1 (LYVE-1), as a lymphatic endothelial-specific marker, is specifically expressed in lymphatic endothelial cells and is uniformly distributed in the basal and luminal surfaces of lymphatic endothelial cells, and its wide application promotes research in the field of tumor lymphatic metastasis. In recent years, the biological function of LYVE-1 itself and the role it plays in the field of tumor metastasis have become one of the hotspots of tumor metastasis research. Elucidating the mechanism of LYVE-1’s role in tumor lymphatic metastasis is of great significance for the establishment of new methods of tumor therapy.
LYVE1 Target Infomation Overview
- Target Symbol: LYVE1, lymphatic vessel endothelial hyaluronan receptor 1
- Alias: LYVE-1
- Previous Names: XLKD1
- Alias Names: extracellular link domain containing 1
LYVE1, lymphatic vessel endothelial hyaluronan receptor 1 Target Infomation by Species
- Human
- Mouse
- Rat
Human LYVE1 Target Information
- Target Symbol: LYVE1, lymphatic vessel endothelial hyaluronan receptor 1
- Alias:
- cell surface retention sequence binding protein-1
- cell surface retention sequence-binding protein 1
- CRSBP-1
- extracellular link domain containing 1
- extracellular link domain-containing 1
- extracellular link domain-containing protein 1
- HAR
- hyaluronic acid receptor
- lymphatic vessel endothelial hyaluronic acid receptor 1
- LYVE-1
- XLKD1
- NCBI_Gene: 10894
- UniProtKB: Q9Y5Y7
Human LYVE1 Predicted Functions
Predicted to enable hyaluronic acid binding activity and transmembrane signaling receptor activity. Predicted to be involved in anatomical structure morphogenesis; cell-matrix adhesion; and response to wounding. Predicted to act upstream of or within glycosaminoglycan catabolic process. Located in extracellular exosome.
Mouse Lyve1 Target Information
- Target Symbol: Lyve1, lymphatic vessel endothelial hyaluronan receptor 1
- Alias:
- 1200012G08Rik
- extra cellular link domain-containing 1
- lymphatic vessel endothelial HA receptor-1
- Lyve-1
- RIKEN cDNA 1200012G08 gene
- Xlkd1
- NCBI_Gene: 114332
Mouse Lyve1 Predicted Functions
Enables hyaluronic acid binding activity and transmembrane signaling receptor activity. Acts upstream of or within glycosaminoglycan catabolic process. Located in plasma membrane. Is expressed in several structures, including cardiovascular system; gut; hemolymphoid system; meninges; and metanephros. Orthologous to human LYVE1 (lymphatic vessel endothelial hyaluronan receptor 1).
Rat Lyve1 Target Information
- Target Symbol: Lyve1, lymphatic vessel endothelial hyaluronan receptor 1
- Alias:
- extra cellular link domain-containing 1
- extracellular link domain-containing 1
- LOC293186
- lymphatic vessel endothelial hyaluronic acid receptor 1
- Xlkd1
- NCBI_Gene: 293186
- UniProtKB: D3ZD19
Rat Lyve1 Predicted Functions
Predicted to enable hyaluronic acid binding activity and transmembrane signaling receptor activity. Predicted to be involved in cell adhesion. Predicted to act upstream of or within glycosaminoglycan catabolic process. Predicted to be located in cell periphery. Predicted to be active in plasma membrane. Orthologous to human LYVE1 (lymphatic vessel endothelial hyaluronan receptor 1).
