HGNC ID: 11820
Target Abstract:
Matrix metalloproteinase inhibitor-1 (TIMP-1) is a glycoprotein expressed in various tissues of the organism and is a member of the TIMP family. TIMP-1 is a natural inhibitor of matrix metalloproteinases (MMPs), a group of peptidases involved in extracellular matrix degradation. In addition to inhibiting most known MMPs, TIMP-1 promotes cell reproduction in a variety of cell types and may also have anti-apoptotic effects. Responses to many cytokines and hormones strongly induce transcription of this gene. Studies have shown that TIMP-1 gene inactivation in human females is polymorphic. ACTH induced the expression of TIMP-1 in adrenal cortical cells, and the increase of TIMP expression was related to the decrease of collagenase activity. In addition, increased TIMP-1 expression is associated with poorer prognosis for a variety of tumors such as laryngeal cancer or melanoma.
TIMP1 Target Infomation Overview
- Target Symbol: TIMP1, TIMP metallopeptidase inhibitor 1
- Gene Groups: Tissue inhibitor of metallopeptidases
- Alias: EPO
- Previous Names: TIMP; CLGI
- Alias Names: tissue inhibitor of metalloproteinase 1 (erythroid potentiating activity, collagenase inhibitor)
TIMP1, TIMP metallopeptidase inhibitor 1 Target Infomation by Species
- Human
- Mouse
- Rat
Human TIMP1 Target Information
- Target Symbol: TIMP1, TIMP metallopeptidase inhibitor 1
- Alias:
- CLGI
- collagenase inhibitor
- EPA
- EPO
- erythroid potentiating activity
- erythroid-potentiating activity
- fibroblast collagenase inhibitor
- FLJ90373
- HCI
- metalloproteinase inhibitor 1
- TIMP
- TIMP-1
- tissue inhibitor of metalloproteinase 1 (erythroid potentiating activity, collagenase inhibitor)
- tissue inhibitor of metalloproteinases 1
- NCBI_Gene: 7076
- UniProtKB: P01033
Human TIMP1 Predicted Functions
Enables cytokine activity; metalloendopeptidase inhibitor activity; and zinc ion binding activity. Involved in several processes, including cellular response to UV-A; negative regulation of proteolysis; and negative regulation of trophoblast cell migration. Located in extracellular space. Biomarker of several diseases, including CAKUT2; Down syndrome; artery disease (multiple); carcinoma (multiple); and diabetes mellitus (multiple).
Mouse Timp1 Target Information
- Target Symbol: Timp1, tissue inhibitor of metalloproteinase 1
- Alias:
- Clgi
- MGC:7143
- TIMP-1
- NCBI_Gene: 21857
Mouse Timp1 Predicted Functions
Predicted to enable several functions, including cytokine activity; metalloendopeptidase inhibitor activity; and zinc ion binding activity. Acts upstream of or within connective tissue replacement involved in inflammatory response wound healing. Located in basement membrane. Is expressed in several structures, including early conceptus; hindlimb cartilage condensation; jaw; reproductive system; and skeletal system. Orthologous to human TIMP1 (TIMP metallopeptidase inhibitor 1).
Rat Timp1 Target Information
- Target Symbol: Timp1, TIMP metallopeptidase inhibitor 1
- Alias:
- metalloproteinase inhibitor 1
- Timp
- TIMP-1
- tissue inhibitor of metallopeptidase 1
- tissue inhibitor of metalloproteinase 1
- tissue inhibitor of metalloproteinases 1
- NCBI_Gene: 116510
- UniProtKB: P30120
Rat Timp1 Predicted Functions
Enables protease binding activity. Involved in several processes, including cartilage development; response to peptide hormone; and wound healing. Located in basement membrane. Used to study degenerative disc disease. Biomarker of cholestasis; gastric ulcer; heart disease (multiple); lung disease (multiple); and vascular disease (multiple). Orthologous to human TIMP1 (TIMP metallopeptidase inhibitor 1).
