HGNC ID: 2475
Target Abstract:
Cysteine protease inhibitor C belongs to the cysteine protease inhibitor superfamily and is an effective inhibitor of lysosomal proteases, possibly one of the most important extracellular inhibitors of cysteine proteases. It exists in almost all tissues and bodily fluids, including plasma, urine, and cerebrospinal fluid. Cystatin C participates in various disease processes by regulating cysteine protease activity. Cystatin C is mainly used as a biomarker for renal function. Recently, research has shown that it plays a role in predicting new or worsening cardiovascular diseases. In addition, it plays a role in amyloid related brain diseases such as Alzheimer’s disease.
CST3 Target Infomation Overview
- Target Symbol: CST3, cystatin C
- Gene Groups: Cystatins, type 2
- Alias Names: cystatin C (amyloid angiopathy and cerebral hemorrhage)
CST3, cystatin C Target Infomation by Species
- Human
- Mouse
- Rat
Human CST3 Target Information
- Target Symbol: CST3, cystatin C
- Alias:
- ARMD11
- bA218C14.4 (cystatin C)
- cystatin 3
- cystatin C (amyloid angiopathy and cerebral hemorrhage)
- cystatin-3
- cystatin-C
- epididymis secretory protein Li 2
- gamma-trace
- HEL-S-2
- MGC117328
- neuroendocrine basic polypeptide
- post-gamma-globulin
- NCBI_Gene: 1471
- UniProtKB: P01034
Human CST3 Predicted Functions
Enables several functions, including amyloid-beta binding activity; cysteine-type endopeptidase inhibitor activity; and identical protein binding activity. Involved in several processes, including negative regulation of blood vessel remodeling; negative regulation of catabolic process; and negative regulation of extracellular matrix disassembly. Located in Golgi apparatus; extracellular space; and plasma membrane. Implicated in CST3-related cerebral amyloid angiopathy and age related macular degeneration 11. Biomarker of several diseases, including artery disease (multiple); autoimmune disease of the nervous system (multiple); brain ischemia; obesity; and type 2 diabetes mellitus.
Mouse Cst3 Target Information
- Target Symbol: Cst3, cystatin C
- Alias:
- CysC
- NCBI_Gene: 13010
Mouse Cst3 Predicted Functions
Predicted to enable several functions, including amyloid-beta binding activity; cysteine-type endopeptidase inhibitor activity; and identical protein binding activity. Predicted to be involved in several processes, including negative regulation of cell death; positive regulation of DNA replication; and response to oxidative stress. Predicted to act upstream of or within negative regulation of peptidase activity. Located in collagen-containing extracellular matrix and extracellular space. Is expressed in several structures, including central nervous system; early conceptus; heart; reproductive system; and visual system. Human ortholog(s) of this gene implicated in CST3-related cerebral amyloid angiopathy and age related macular degeneration 11. Orthologous to several human genes including CST3 (cystatin C).
Rat Cst3 Target Information
- Target Symbol: Cst3, cystatin C
- Alias:
- CYSC
- cystatin 3
- Cystatin C (cysteine proteinase inhibitor)
- cystatin-3
- cystatin-C
- MGC105556
- NCBI_Gene: 25307
- UniProtKB: P14841
Rat Cst3 Predicted Functions
Enables peptidase inhibitor activity and protease binding activity. Involved in several processes, including animal organ development; circadian sleep/wake cycle, REM sleep; and embryo implantation. Located in several cellular components, including multivesicular body; neuronal cell body; and nuclear membrane. Biomarker of intracranial aneurysm; iron deficiency anemia; and obesity. Human ortholog(s) of this gene implicated in CST3-related cerebral amyloid angiopathy and age related macular degeneration 11. Orthologous to several human genes including CST3 (cystatin C).
