HGNC ID: 10637
Target Abstract:
Chemokine ligand 10 (CXCL10), also known as γ-interferon inducible protein 10 (IP-10) or microinducible cytokine B10, is a small molecular weight cytokine belonging to the CXC chemokine family. IP-10 is secreted by many types of cells in response to IFN-γ, including monocytes, endothelial cells, and fibroblasts, etc. IP-10 has multiple functions, such as chemotaxis to monocytes/macrophages, T cells, NK cells, and dendritic cells, promotion of T-cell adhesion to endothelial cells, antitumor activity, and inhibition of bone marrow colony formation and angiogenesis.
CXCL10 Target Infomation Overview
- Target Symbol: CXCL10, C-X-C motif chemokine ligand 10
- Gene Groups: Chemokine ligands
- Alias: IFI10; IP-10; crg-2; mob-1; C7; gIP-10
- Previous Names: INP10; SCYB10
- Alias Names: small inducible cytokine subfamily B (Cys-X-Cys), member 10; chemokine (C-X-C motif) ligand 10
CXCL10, C-X-C motif chemokine ligand 10 Target Infomation by Species
- Human
- Mouse
- Rat
Human CXCL10 Target Information
- Target Symbol: CXCL10, C-X-C motif chemokine ligand 10
- Alias:
- 10 kDa interferon gamma-induced protein
- C-X-C motif chemokine 10
- C7
- chemokine (C-X-C motif) ligand 10
- crg-2
- gamma IP10
- gamma-IP10
- gIP-10
- IFI10
- INP10
- interferon-inducible cytokine IP-10
- IP-10
- mob-1
- protein 10 from interferon (gamma)-induced cell line
- SCYB10
- small inducible cytokine subfamily B (Cys-X-Cys), member 10
- small-inducible cytokine B10
- NCBI_Gene: 3627
- UniProtKB: P02778
Human CXCL10 Predicted Functions
Enables chemoattractant activity; chemokine receptor binding activity; and heparin binding activity. Involved in several processes, including positive regulation of release of sequestered calcium ion into cytosol; regulation of leukocyte chemotaxis; and response to virus. Acts upstream of or within cellular response to lipopolysaccharide and positive regulation of T cell migration. Located in extracellular region. Implicated in hepatitis B and middle cerebral artery infarction. Biomarker of several diseases, including artery disease (multiple); diabetes mellitus (multiple); fatty liver disease (multiple); liver disease (multiple); and lung disease (multiple).
Mouse Cxcl10 Target Information
- Target Symbol: Cxcl10, chemokine (C-X-C motif) ligand 10
- Alias:
- C7
- CRG-2
- gIP-10
- Ifi10
- INP10
- interferon activated gene 10
- IP-10
- IP10
- mob-1
- Scyb10
- small inducible cytokine B subfamily (Cys-X-Cys), member 10
- NCBI_Gene: 15945
Mouse Cxcl10 Predicted Functions
Predicted to enable chemoattractant activity; chemokine receptor binding activity; and heparin binding activity. Acts upstream of or within several processes, including defense response to virus; negative regulation of myoblast differentiation; and negative regulation of myoblast fusion. Located in external side of plasma membrane and extracellular space. Is expressed in several structures, including alimentary system; axial skeleton; hemolymphoid system; and liver. Human ortholog(s) of this gene implicated in hepatitis B; middle cerebral artery infarction; and type 1 diabetes mellitus. Orthologous to human CXCL10 (C-X-C motif chemokine ligand 10).
Rat Cxcl10 Target Information
- Target Symbol: Cxcl10, C-X-C motif chemokine ligand 10
- Alias:
- 10 kDa interferon gamma-induced protein
- C-X-C motif chemokine 10
- chemokine (C-X-C motif) ligand 10
- gamma-IP10
- interferon-inducible cytokine IP-10
- interferon-inducible protein 10
- IP-10
- protein Mob-1
- Scyb10
- small inducible cytokine B subfamily (Cys-X-Cys) member 10
- small inducible cytokine B subfamily (Cys-X-Cys), member 10
- small-inducible cytokine B10
- NCBI_Gene: 245920
- UniProtKB: P48973
Rat Cxcl10 Predicted Functions
Enables chemokine activity. Involved in several processes, including response to auditory stimulus; response to gamma radiation; and response to vitamin D. Located in extracellular space. Used to study adult respiratory distress syndrome; myocarditis; proteinuria; renovascular hypertension; and type 1 diabetes mellitus. Biomarker of brain ischemia; encephalitis; and uveitis. Human ortholog(s) of this gene implicated in hepatitis B and middle cerebral artery infarction. Orthologous to human CXCL10 (C-X-C motif chemokine ligand 10).
