HGNC ID: 10718
Target Abstract:
E-selectin, also known as CD62E, endothelial-leukocyte adhesion molecule 1 (ELAM-1) or leukocyte-endothelial cell adhesion molecule 2 (LECAM2), is a 115 kDa glycoprotein that is expressed only after activation by inflammatory cytokines (IL-1β or TNF-α) or endotoxin in endothelial cells. Cell surface E-selectin mediates leukocyte attachment to the endothelium and thus plays an important role in the local inflammatory response.The extracellular region of E-selectin consists of a calcium-dependent C2-type lectin structural domain, an epidermal growth factor (EGF) structural domain, and six repetitive complement regulatory protein-like sequences. Soluble E-selectin (sE-Selectin) is present in the blood of healthy organisms and may arise from protein cleavage of surface-expressed molecules. Monitoring serum levels of sE-Selectin may provide more detailed insights into a number of pathologic conditions such as cancer, infectious diseases, diabetes, and sepsis.
SELE Target Infomation Overview
- Target Symbol: SELE, selectin E
- Gene Groups: CD molecules; Selectins; Sushi domain containing; C-type lectin domain containing
- Alias: ESEL; CD62E
- Previous Names: ELAM1; ELAM
- Alias Names: endothelial adhesion molecule 1
SELE, selectin E Target Infomation by Species
- Human
- Mouse
- Rat
Human SELE Target Information
- Target Symbol: SELE, selectin E
- Alias:
- CD62 antigen-like family member E
- CD62E
- E-selectin
- ELAM
- ELAM-1
- ELAM1
- endothelial adhesion molecule 1
- endothelial leukocyte adhesion molecule 1
- ESEL
- LECAM2
- leukocyte endothelial cell adhesion molecule 2
- leukocyte-endothelial cell adhesion molecule 2
- NCBI_Gene: 6401
- UniProtKB: P16581
Human SELE Predicted Functions
Enables several functions, including oligosaccharide binding activity; phospholipase binding activity; and sialic acid binding activity. Involved in several processes, including activation of phospholipase C activity; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; and leukocyte tethering or rolling. Located in several cellular components, including caveola; clathrin-coated pit; and perinuclear region of cytoplasm. Is integral component of plasma membrane. Implicated in IgA glomerulonephritis; brain ischemia; cerebrovascular disease; and coronary artery disease. Biomarker of COVID-19; rheumatic myocarditis; and type 1 diabetes mellitus.
Mouse Sele Target Information
- Target Symbol: Sele, selectin, endothelial cell
- Alias:
- CD62E
- E-selectin
- Elam
- endothelial adhesion molecule
- NCBI_Gene: 20339
Mouse Sele Predicted Functions
Predicted to enable several functions, including oligosaccharide binding activity; phospholipase binding activity; and sialic acid binding activity. Involved in positive regulation of leukocyte tethering or rolling. Acts upstream of or within positive regulation of leukocyte migration. Predicted to be located in several cellular components, including caveola; clathrin-coated pit; and perinuclear region of cytoplasm. Predicted to be integral component of plasma membrane. Predicted to be active in external side of plasma membrane and extracellular space. Is expressed in several structures, including adrenal gland; genitourinary system; incisor; integumental system; and limb segment. Human ortholog(s) of this gene implicated in IgA glomerulonephritis; brain ischemia; cerebrovascular disease; and coronary artery disease. Orthologous to human SELE (selectin E).
Rat Sele Target Information
- Target Symbol: Sele, selectin E
- Alias:
- CD62 antigen-like family member E
- E-selectin
- ELAM-1
- endothelial leukocyte adhesion molecule 1
- LECAM2
- leukocyte-endothelial cell adhesion molecule 2
- selectin, endothelial cell
- NCBI_Gene: 25544
Rat Sele Predicted Functions
Predicted to enable several functions, including oligosaccharide binding activity; phospholipase binding activity; and sialic acid binding activity. Involved in inflammatory response; leukocyte migration; and response to cytokine. Predicted to be located in several cellular components, including caveola; clathrin-coated pit; and perinuclear region of cytoplasm. Predicted to be integral component of plasma membrane. Predicted to be active in external side of plasma membrane and extracellular space. Human ortholog(s) of this gene implicated in IgA glomerulonephritis; brain ischemia; cerebrovascular disease; and coronary artery disease. Orthologous to human SELE (selectin E).
