HGNC ID: 10621
Target Abstract:
Chemokine ligand 22 (CCL22), also known as macrophage-derived chemokine (MDC), is a member of the CC chemokine family.B-cells, microglia, dendritic cells, macrophages, monocytes, interferonγ-activated keratinocytes, colonic epithelial cells, CD4+ T-cells, thymic medullary epithelial cells (microsomes), and activated NK cells are all known to express CCL22. CCL22 is important for lymphocyte migration and it is a potent chemotactic agent for cell types such as dendritic cells, thymocytes and activated NK cells. CCL22 produced by antigen-presenting dendritic cells chemotaxis activated (or memory) T cells carrying CCR4, which enhances the immune response and increases effector function.CCL22 also has other functions, including activation of platelet function and inhibition of synaptic transmission between hippocampal neurons.
CCL22 Target Infomation Overview
- Target Symbol: CCL22, C-C motif chemokine ligand 22
- Gene Groups: Chemokine ligands
- Alias: MDC; STCP-1; ABCD-1; DC/B-CK; A-152E5.1; MGC34554
- Previous Names: SCYA22
- Alias Names: small inducible cytokine subfamily A (Cys-Cys), member 22; chemokine (C-C motif) ligand 22
CCL22, C-C motif chemokine ligand 22 Target Infomation by Species
- Human
- Mouse
- Rat
Human CCL22 Target Information
- Target Symbol: CCL22, C-C motif chemokine ligand 22
- Alias:
- A-152E5.1
- ABCD-1
- C-C motif chemokine 22
- CC chemokine STCP-1
- chemokine (C-C motif) ligand 22
- DC/B-CK
- macrophage-derived chemokine
- MDC
- MDC(1-69)
- MGC34554
- SCYA22
- small inducible cytokine A22
- small inducible cytokine subfamily A (Cys-Cys), member 22
- small-inducible cytokine A22
- STCP-1
- stimulated T cell chemotactic protein 1
- stimulated T-cell chemotactic protein 1
- NCBI_Gene: 6367
- UniProtKB: O00626
Human CCL22 Predicted Functions
Predicted to enable CCR chemokine receptor binding activity and chemokine activity. Involved in antimicrobial humoral immune response mediated by antimicrobial peptide and killing of cells of other organism. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Biomarker of several diseases, including arthritis (multiple); cervical squamous cell carcinoma; lung disease (multiple); pleural tuberculosis; and rhinitis.
Mouse Ccl22 Target Information
- Target Symbol: Ccl22, chemokine (C-C motif) ligand 22
- Alias:
- ABCD-1
- MDC
- Scya22
- small inducible cytokine subfamily A22
- NCBI_Gene: 20299
Mouse Ccl22 Predicted Functions
Predicted to enable CCR chemokine receptor binding activity and chemokine activity. Predicted to be involved in several processes, including cellular response to cytokine stimulus; leukocyte chemotaxis; and positive regulation of ERK1 and ERK2 cascade. Predicted to act upstream of or within chemotaxis. Located in extracellular space. Is expressed in inguinal lymph node; thymus; and thymus primordium. Orthologous to human CCL22 (C-C motif chemokine ligand 22).
Rat Ccl22 Target Information
- Target Symbol: Ccl22, C-C motif chemokine ligand 22
- Alias:
- C-C motif chemokine 22
- chemokine (C-C motif) ligand 22
- Mdc
- MGC108943
- Scya22
- small inducible cytokine A22
- small inducible cytokine subfamily A (Cys-Cys) member 22
- small inducible cytokine subfamily A (Cys-Cys), member 22
- NCBI_Gene: 117551
- UniProtKB: Q5I0L5
Rat Ccl22 Predicted Functions
Predicted to enable CCR chemokine receptor binding activity and chemokine activity. Predicted to be involved in several processes, including cellular response to cytokine stimulus; leukocyte chemotaxis; and positive regulation of ERK1 and ERK2 cascade. Predicted to be active in extracellular space. Used to study anti-basement membrane glomerulonephritis. Biomarker of asthma; pneumonia; and pulmonary fibrosis. Orthologous to human CCL22 (C-C motif chemokine ligand 22).
