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    CCL22 Overview

    Chemokine ligand 22 (CCL22), also known as macrophage-derived chemokine (MDC), is a member of the CC chemokine family.B-cells, microglia, dendritic cells, macrophages, monocytes, interferonγ-activated keratinocytes, colonic epithelial cells, CD4+ T-cells, thymic medullary epithelial cells (microsomes), and activated NK cells are all known to express CCL22. CCL22 is important for lymphocyte migration and it is a potent chemotactic agent for cell types such as dendritic cells, thymocytes and activated NK cells. CCL22 produced by antigen-presenting dendritic cells chemotaxis activated (or memory) T cells carrying CCR4, which enhances the immune response and increases effector function.CCL22 also has other functions, including activation of platelet function and inhibition of synaptic transmission between hippocampal neurons.

    CCL22 Molecular Product List