HGNC ID: 5986
Target Abstract:
Interleukin 18 (IL-18), also known as interferonγinducible factor, is a proinflammatory cytokine that in humans is encoded by the IL18 gene.IL-18 belongs to the IL-1 superfamily, which is secreted and produced by macrophages and other cells.Upon stimulation by IL-18, natural killer (NK) cells and certain T cells release another important cytokine & mdash;interferonγ or type II interferon, which in turn activates macrophages or other cells.IL-18 induces a severe inflammatory response and likewise increases the production of β-amyloid (associated with Alzheimer’s disease) in human neurons.
IL18 Target Infomation Overview
- Target Symbol: IL18, interleukin 18
- Gene Groups: Interleukins
- Alias: IGIF; IL1F4; IL-1g; IL-18
- Alias Names: interferon-gamma-inducing factor; interleukin 18 (interferon-gamma-inducing factor)
IL18, interleukin 18 Target Infomation by Species
- Human
- Mouse
- Rat
Human IL18 Target Information
- Target Symbol: IL18, interleukin 18
- Alias:
- iboctadekin
- IFN-gamma-inducing factor
- IGIF
- IL-1 gamma
- IL-18
- IL-1g
- IL1F4
- interferon gamma-inducing factor
- interleukin 18 (interferon-gamma-inducing factor)
- interleukin-1 gamma
- interleukin-18
- MGC12320
- NCBI_Gene: 3606
- UniProtKB: Q14116
Human IL18 Predicted Functions
Enables cytokine activity and interleukin-18 receptor binding activity. Involved in several processes, including positive regulation of cell population proliferation; positive regulation of intracellular signal transduction; and positive regulation of macromolecule metabolic process. Located in extracellular space. Implicated in several diseases, including Kawasaki disease; allergic rhinitis; autoimmune disease (multiple); biliary atresia; and hepatitis B. Biomarker of several diseases, including autoimmune disease (multiple); cholestasis (multiple); liver disease (multiple); lung disease (multiple); and myositis (multiple).
Mouse Il18 Target Information
- Target Symbol: Il18, interleukin 18
- Alias:
- Igif
- Il-18
- interferon gamma inducing factor
- NCBI_Gene: 16173
Mouse Il18 Predicted Functions
Enables cytokine activity. Involved in lipid homeostasis; positive regulation of cell differentiation; and positive regulation of cold-induced thermogenesis. Acts upstream of or within several processes, including interleukin-18-mediated signaling pathway; positive regulation of NIK/NF-kappaB signaling; and positive regulation of interferon-gamma production. Located in extracellular space. Is expressed in several structures, including back skin; dorsal aorta; gut; lymphatic system; and reproductive system. Used to study atopic dermatitis. Human ortholog(s) of this gene implicated in several diseases, including Kawasaki disease; allergic rhinitis; autoimmune disease (multiple); biliary atresia; and hepatitis B. Orthologous to human IL18 (interleukin 18).
Rat Il18 Target Information
- Target Symbol: Il18, interleukin 18
- Alias:
- IFN-gamma-inducing factor
- IL-1 gamma
- IL-18
- interferon gamma-inducing factor
- interferon-gamma-inducing factor
- interleukin-1 gamma
- interleukin-18
- NCBI_Gene: 29197
Rat Il18 Predicted Functions
Predicted to enable cytokine activity and interleukin-18 receptor binding activity. Involved in several processes, including cellular response to hormone stimulus; positive regulation of cell population proliferation; and positive regulation of cytokine production. Located in apical plasma membrane; cytoplasm; and extracellular space. Used to study brain edema; fatty liver disease; heart disease; status epilepticus; and vasculitis. Biomarker of several diseases, including cardiac arrest; ischemia (multiple); lung disease (multiple); perinatal necrotizing enterocolitis; and urinary tract infection. Human ortholog(s) of this gene implicated in several diseases, including Kawasaki disease; allergic rhinitis; autoimmune disease (multiple); biliary atresia; and hepatitis B. Orthologous to human IL18 (interleukin 18).
