HGNC ID: 16642
Target Abstract:
Chemokine (C-X-C motif) ligand 16 (CXCL16) is a small molecular weight cytokine belonging to the CXC family of chemokines, consisting of 254 amino acids and is a type I membrane protein. The gene for human CXCL16 is located on chromosome 17. CXCL16 is produced by dendritic cells within the T-cell zone of lymphoid organs and by cells in the red pulp of the spleen. The inflammatory cytokines IFN-γ and TNF-α induce the expression of CXCL16, which interacts with the chemokine receptor CXCR6 (also known as Bonzo). Injections of folic acid force methylation of CXCL16, inducing high levels of methylation of the CXCL16 gene promoter in the colon, ileum, and lungs, as well as accumulation of iNKT cells in these tissues.
CXCL16 Target Infomation Overview
- Target Symbol: CXCL16, C-X-C motif chemokine ligand 16
- Gene Groups: Chemokine ligands; Scavenger receptors
- Alias: SR-PSOX; CXCLG16; SRPSOX
- Alias Names: CXC chemokine ligand 16; chemokine (C-X-C motif) ligand 16
CXCL16, C-X-C motif chemokine ligand 16 Target Infomation by Species
- Human
- Mouse
- Rat
Human CXCL16 Target Information
- Target Symbol: CXCL16, C-X-C motif chemokine ligand 16
- Alias:
- C-X-C motif chemokine 16
- chemokine (C-X-C motif) ligand 16
- CXC chemokine ligand 16
- CXCLG16
- scavenger receptor for phosphatidylserine and oxidized low density lipoprotein
- small-inducible cytokine B16
- SR-PSOX
- SRPSOX
- transmembrane chemokine CXCL16
- NCBI_Gene: 58191
- UniProtKB: Q9H2A7
Human CXCL16 Predicted Functions
Enables chemokine activity. Involved in several processes, including positive regulation of cell growth; response to interferon-gamma; and response to tumor necrosis factor. Located in extracellular space. Biomarker of COVID-19 and systemic scleroderma.
Mouse Cxcl16 Target Information
- Target Symbol: Cxcl16, chemokine (C-X-C motif) ligand 16
- Alias:
- 0910001K24Rik
- AV290116
- BB024863
- expressed sequence AV290116
- expressed sequence BB024863
- RIKEN cDNA 0910001K24 gene
- Scavenger Receptor
- SR-PSOX
- SR-PSOX/CXCL16
- NCBI_Gene: 66102
Mouse Cxcl16 Predicted Functions
Enables chemokine activity; low-density lipoprotein particle receptor activity; and scavenger receptor activity. Involved in T cell chemotaxis and cellular response to lipopolysaccharide. Located in extracellular space. Is integral component of membrane. Is expressed in bladder; female associated reproductive structure; hindbrain meninges; male associated reproductive structure; and spinal cord meninges. Orthologous to human CXCL16 (C-X-C motif chemokine ligand 16).
Rat Cxcl16 Target Information
- Target Symbol: Cxcl16, C-X-C motif chemokine ligand 16
- Alias:
- C-X-C motif chemokine 16
- chemokine (C-X-C motif) ligand 16
- similar to chemokine (C-X-C motif) ligand 16
- small-inducible cytokine B16
- transmembrane chemokine CXCL16
- NCBI_Gene: 497942
Rat Cxcl16 Predicted Functions
Predicted to enable chemokine activity; low-density lipoprotein particle receptor activity; and scavenger receptor activity. Predicted to be involved in several processes, including T cell chemotaxis; cellular response to lipopolysaccharide; and response to interferon-gamma. Predicted to be integral component of membrane. Predicted to be active in extracellular space. Orthologous to human CXCL16 (C-X-C motif chemokine ligand 16).
